Qunfeng Ma

Publications (2)4.95 Total impact

• Article: The role of microRNA in human lung squamous cell carcinoma.

  Ye Yang, Xiaofei Li, Qi Yang, Xiaoping Wang, Yongan Zhou, Tao Jiang, Qunfeng Ma, Yun-Jie Wang
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  ABSTRACT: MicroRNAs (miRNAs) are a group of small noncoding RNAs with modulator activity of gene expression. Deregulation of miRNA genes was found in several types of cancers. To explore the role of the miRNAs in Chinese lung squamous cell carcinoma (SCC), the expression profile of 711 miRNAs in SCC was analyzed. Total RNAs were used for hybridization on a commercially available array (miRCURY LNA array v.10.0), which contains 1,200 probes in tetramer, corresponding to 711 human miRNA genes. The results of miRNA microarray analysis were confirmed with quantitative real-time polymerase chain reaction. Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC (P < 0.05), compared with normal lung tissues. The miRNAs miR-185 * and miR-125a-5p were significantly upregulated in lung SCC (P < 0.05), compared with normal lung tissues. The miRNA let-7i was downregulated in 9 of the 20 SCC samples, and miR-126 was downregulated in 16 of 20. The deregulation of some miRNAs in lung SCC suggests their possible involvement in the development and progression of SCC.
  Cancer genetics and cytogenetics 07/2010; 200(2):127-33. · 1.54 Impact Factor
• Article: Repair of massive stent-induced tracheoesophageal fistula.

  Yong Han, Kun Liu, Xiaofei Li, Xiaoping Wang, Yongan Zhou, Zhongping Gu, Qunfeng Ma, Tao Jiang, Lijun Huang, Tao Zhang, Qingshu Cheng
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  ABSTRACT: The purpose of this report was to discuss a new surgical procedure in treating esophageal stent related large tracheoesophageal fistula without tracheal resection. Clinical records of 5 patients with esophageal stent-related large tracheoesophageal fistulas treated in this hospital between 1997 and 2006 were reviewed. All patients had insertion of a covered self-expanding esophageal stent, 1 for benign esophageal stricture and 4 for esophageal perforation resulting from various causes. A double patch technique, in which the esophageal wall was used as a protective patch repairing the defect on the trachea, was performed with an esophagectomy and gastric replacement. No significant complications occurred in the perioperative period. All patients recovered uneventfully. Use of the adjacent esophageal wall as a patch to close a defect on the trachea is a safe procedure with a favorable outcome. It should therefore be recommended as a reliable surgical procedure in treating massive stent-induced tracheoesophageal fistulas and other complicated tracheoesophageal fistulas that tracheal resection could not safely address. However, the esophagus was damaged to a certain degree.
  The Journal of thoracic and cardiovascular surgery 05/2009; 137(4):813-7. · 3.41 Impact Factor