Qiu-Mei Xu

Huazhong University of Science and Technology, Wu-han-shih, Hubei, China

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Publications (1)2.28 Total impact

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    ABSTRACT: Congenital long QT syndrome is characterized by a prolongation of ventricular repolarization and recurrent episodes of life-threatening ventricular tachyarrhythmias, often leading to sudden death. We previously identified a missense mutation F275S located within the S5 transmembrane domain of the KCNQ1 ion channel in a Chinese family with long QT syndrome. We used oocyte expression of the KCNQ1 polypeptide to study the effects of the F275S mutation on channel properties. Expression of the F275 mutant, or co-expression with the wild-type S275 polypeptide, significantly decreased channel current amplitudes. Moreover, the F275S substitution decreased the rates of channel activation and deactivation. In transfected HEK293 cells fluorescence microscopy revealed that the F275S mutation perturbed the subcelluar localization of the ion channel. These results indicate that the F275S KCNQ1 mutation leads to impaired polypeptide trafficking that in turn leads to reduction of channel ion currents and altered gating kinetics.
    Biochemical and Biophysical Research Communications 02/2009; 380(1):127-31. DOI:10.1016/j.bbrc.2009.01.051 · 2.28 Impact Factor

Publication Stats

6 Citations
2.28 Total Impact Points

Institutions

  • 2009
    • Huazhong University of Science and Technology
      • Department of Cardiology
      Wu-han-shih, Hubei, China