Publications (2)0 Total impact
Article: [Inhibitory control deficit in patients with panic disorder: an event-related potentials study].[show abstract] [hide abstract]
ABSTRACT: To investigate the electrophysiological evidence of inhibitory control deficit in panic disorder patients using a visual simple Go/Nogo task. Sixteen patients with panic disorder and 13 healthy volunteers received a visual simple Go/Nogo task. The stimuli were single or double English letters and appeared with equal probability. The subjects were instructed to press a button as quickly as possible when the double letter was presented (i.e., Go), but make no response to the single letter (i.e., Nogo). 32 channel EEG data were recorded. All subjects displayed a distinct Go/Nogo effect in the N2 component (PD group:F(1,30) = 8.00, P = 0.008; NC group: F(1,24) = 4.60, P = 0.042) and P3 component (PD group: F(1,30) = 7.85, P = 0.009; NC group: F(1,24) = 13.57, P = 0.000) at frontocentral sites, but the amplitudes of Nogo-N2 and Nogo-P3 were significantly reduced in panic disorder patients as compared to the healthy subjects (Fz: F = 9.135, P = 0.005; F = 8.511, P = 0.006, respectively). There was no significant differences between the latencies of Nogo-N2 and Nogo-P3. Panic disorder may consist inhibitory control deficit which may assist in offering new objective evidence to understand the etiology of panic disorder.Zhonghua yi xue za zhi 12/2008; 88(41):2912-5.
Article: [Automatic auditory information management in panic disorder patients: an event-related potentials study].[show abstract] [hide abstract]
ABSTRACT: To investigate the characteristics of automatic auditory information management in sufferers of panic disorder (PD). Mismatch negativity (MMN), as a component of event-related potentials, was recorded from 15 PD patients, 8 males and 7 females, aged 40 +/- 12, and 15 sex, and aged-matched controls. Repeated measures ANOVA was used on 4 representative electrodes: T3, T4, F3, and F4. Compared with the normal controls, the PD patients showed significant enlargement of MMN amplitude in 60 - 210 ms latency windows (60 - 110 ms: F(1, 28) = 11.413, P = 0.02; 110 - 160 ms: F(1, 28) = 6.639, P = 0.016; 160 - 210 ms: F(1, 28) = 5.758, P = 0.023), and exhibited early (60 - 160 ms) left encephalic region predominant effect. PD patients may deal excessive automatic processing of the auditory information changes which may assist in offering new objective evidence to understand the etiology of PD.Zhonghua yi xue za zhi 02/2007; 87(5):330-2.