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Publications (6)8.26 Total impact

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    ABSTRACT: To test the diagnostic accuracy of modified American-European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands. One hundred and ninety subjects were evaluated for the diagnosis of pSS, including US of the salivary glands. We tested the diagnostic accuracy of the three different sets of five diagnostic criteria for pSS. Each set combined these four criteria (ocular symptoms, oral symptoms, Schirmer-I test and auto-SS-A antibody) and one of the following: US (US set), sSC (sSC set) or biopsy (Biopsy set). The area under the receiver operating characteristics curve (AUC-ROC) was used to evaluate the diagnostic accuracy of each set of criteria. Out of 190 subjects examined, 140 subjects fulfilled the AEC for the diagnosis of pSS, whereas 50 subjects were classified as non-pSS subjects. US score was positive in 129 (92%), sSC in 123 (88%) and biopsy in 93 (66%) of 140 pSS patients. Among 140 patients with pSS, 88 (63%) patients fulfilled the criteria of the US set, 85 (61%) patients of the sSC set and 71 (51%) patients of the Biopsy set. None of the subjects from the non-pSS group fulfilled any of the sets of criteria. Diagnostic accuracy of each of the three sets of criteria was high and similar [AUC-ROC (s.e.) for the US set was 0.99 (0.00), followed by the sSC set at 0.98 (0.00) and the Biopsy set at 0.97 (0.00)]. US finding of major salivary gland involvement could replace sSC in AEC for the diagnosis of pSS.
    Rheumatology (Oxford, England) 02/2012; 51(6):1081-5. · 4.24 Impact Factor
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    ABSTRACT: To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy and salivary gland biopsy, in order to evaluate its diagnostic value in primary Sjögren's syndrome (SS). In 135 patients with suspected SS, the grades of 5 US measures of both parotid and submandibular salivary glands were scored (0-48 scale). Diagnosis of primary SS was established following the American-European Consensus Group criteria of 2002. The patients' total scintigraphic score (0-12 scale) was determined and the histopathological changes of minor salivary glands graded. Area under the receiver-operating characteristic (ROC) curve was employed to evaluate the diagnostic value of the US scoring system. Primary SS was diagnosed in 107 (79.2%) patients and the remaining 28 subjects (20.8%) constituted the control group. US changes of salivary glands were established in 98/107 patients with SS and in 14/28 controls. Mean US score was 26 in SS patients and 6 in controls. Through ROC curves, US arose as the best performer (0.95 +/- 0.01), followed by scintigraphy (0.86 +/- 0.31). Setting the cutoff score for US at 19 resulted in the best ratio of specificity (90.8%) to sensitivity (87.1%), while setting the cutoff scintigraphic score at 6 resulted in specificity of 86.1% and sensitivity of 67.1%. Among 70 patients with US score >or= 19, a scintigraphic score > 6 was recorded in 54/70 (77.1%) and positive biopsy findings in 62/70 (88.5%) patients. We show high diagnostic accuracy of a novel US scoring system of salivary glands (0-48) in patients with primary SS comparable to invasive methods, i.e., scintigraphy and salivary gland biopsy.
    The Journal of Rheumatology 06/2009; 36(7):1495-500. · 3.26 Impact Factor
  • P D Jeremić, M M Colić, G D Lazović
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    ABSTRACT: Adhesions of tendons with surrounding tissue, especially in zone II, are frequent complication at the reconstruction of flexor tendons of the hand. Through knowing of biomechanical incidents between the reconstructed flexor tendon and the surrounding tissue we get significant data for post-operative procedures, and that improves the opportunity for obtaining good functional results. By successive loading of operated flexor digitorum profundus in the experimental animals - dogs, medium values of force necessary for mobilization of tendons obtained on 3. post-operative day are 0 = +/- 3.36 N, 5. day 0 = +/- 6.85 N, 10. day 0 = +/- 9.58 N and 15. day 0 = +/- 10.19 N. It can be concluded that peritendon adhesions occur between 3 and 5 post-operative day. In time, the adhesions get stronger and block the movements of the tendon, and growing force is necessary for their mobilization.
    Acta chirurgica iugoslavica 02/2009; 56(1):91-5.
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    P.D. Jeremić, M.M. Colić, G.D. Lazović
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    ABSTRACT: Adhesions of tendons with surrounding tissue, especially in zone II, are frequent complication at the reconstruction of flexor tendons of the hand. Through knowing of biomechanical incidents between the reconstructed flexor tendon and the surrounding tissue we get significant data for post-operative procedures, and that improves the opportunity for obtaining good functional results. By successive loading of operated flexor digitorum profundus in the experimental animals - dogs, medium values of force necessary for mobilization of tendons obtained on 3. post-operative day are 0=+3,36 N, 5. day 0=+6,85 N, 10. day 0=+9,58 N and 15. day 0=+10,19 N. It can be concluded that peritendon adhesions occur between 3. and 5. post-operative day. In time, the adhesions get stronger and block the movements of the tendon, and growing force is necessary for their mobilization.
    Acta chirurgica iugoslavica 01/2009;
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    ABSTRACT: Malignant tumors of the head and neck represent 5% of all malignancies, of which the most common are tumors of the larynx and oral cavity. In the blood serum of patients with malignant tumors increased levels of immunoglobulins and circulating immune complexes have been detected, with a diverse relevance to the clinical course and prognosis of the disease. Due to contradictory findings of the correlation between the humoral immune response and the clinical course of the disease, we examined 42 male patients with laryngeal carcinoma. All patients underwent surgery, of which 15 patients were treated postoperatively with radiotherapy. The changes in the levels of immunoglobulins and circulating immune complexes in the blood serum were recorded and evaluated. Analysis of the results showed an immunological disorder of an abnormal level of circulating immune complexes in the blood serum that normalized after the surgical removal of the tumor. The levels of immunoglobulins G and A were abnormal during the whole postoperative period of examination. The normalizing of the levels of circulating immune complexes in the blood serum, after surgical removal of the tumor, shows a strong association between the two, and this could consequently mean that it could be used as a prognostic tool, particularly in correlation with other immunological parameters.
    Acta chirurgica iugoslavica 01/2009; 56(3):45-9.
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    ABSTRACT: To analyse the incidence and mortality of melanoma in the province of Vojvodina - the north part of Serbia- from the epidemiologic and clinical point of view. In this retrospective study, we used databases of the Cancer Registry of Vojvodina, Oncology Institute of Vojvodina in Sremska Kamenica; Clinical Centre of Vojvodina in Novi Sad; Institute of Public Health of Vojvodina in Novi Sad; and Institute of Public Health of Serbia in Belgrade. The incidence and mortality of melanoma in Vojvodina is permanently increasing over the last three decades. The number of newly diagnosed and deceased patients was higher in men and in women in Vojvodina than in central Serbia. Considering the incidence rate, the region of Vojvodina would be placed in the middle of the European countries. The results are more unfavorable with mortality, especially in male population, similar to the range of higher mortality rates among European countries. These upsetting facts call for improvement of primary and secondary prevention. Education of the population, continuous efforts to recognize groups of population at high risk for developing melanoma and detection of early phases of the disease increases the chances for cure and significantly reduces treatment costs.
    Journal of B.U.ON.: official journal of the Balkan Union of Oncology 01/2009; 14(3):441-6. · 0.76 Impact Factor