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Soizick Chamming's,
Bénédicte Clin,
Patrick Brochard,
Philippe Astoul,
Stéphane Ducamp,
Fançoise Galateau-Salle,
Annabelle Gilg Soit Ilg,
Marcel Goldberg,
Céline Gramond,
Ellen Imbernon, Patrick Rolland,
Jean-Claude Pairon
[show abstract]
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ABSTRACT: BACKGROUND: The aim of this study was to determine the rates of compensation awarded to patients presenting with pleural mesothelioma and factors linked to such compensation in France. METHODS: The study population consisted of 2,407 patients presenting with pleural mesothelioma, recorded by the National Mesothelioma Surveillance Programme between January 1, 1999 and December 31, 2009. Analysis of claims for recognition as "occupational disease" (OD) and claims for compensation by the Compensation Fund for Asbestos Victims (FIVA) were analyzed. RESULTS: Approximately 30% of subjects presenting with pleural mesothelioma, affiliated to the General National Health Insurance fund, neither sought recognition as an OD nor claimed for FIVA compensation. Gender, age at diagnosis, type of health insurance, and socio-professional category influence the likelihood of patients presenting with mesothelioma seeking compensation for this disease. CONCLUSIONS: Results show an under-compensation of pleural mesothelioma as OD and by the FIVA in France. Am. J. Ind. Med. © 2012 Wiley Periodicals, Inc.
American Journal of Industrial Medicine 08/2012; · 1.63 Impact Factor
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Aude Lacourt, Patrick Rolland,
Céline Gramond,
Philippe Astoul,
Soizick Chamming’s,
Stéphane Ducamp,
Catherine Frenay,
Françoise Galateau-Sallé,
Anabelle Gilg Soit Ilg,
Ellen Imbernon,
Nolwenn Le Stang,
Jean Claude Pairon,
Marcel Goldberg,
Yuriko Iwatsubo,
Louis-Rachid Salmi,
Patrick Brochard
[show abstract]
[hide abstract]
ABSTRACT: Pleural mesothelioma is a primary tumor of the pleura that is mainly due to asbestos exposure. To study the relationship between
mesothelioma and occupational asbestos exposure in France, two case–control studies (A and B) were conducted. A substantial
difference in the attributable risk in the population (ARp) was observed among men: 44.5% (95% CI: [32.6–56.4]) in study A and 83.2% (95% CI: [76.8–89.6]) in study B. As different
exposure assessment expert methods were used, the main objective of this work was to re-estimate the ARp men in two case–control studies according to a common standardized exposure assessment by using a Job Exposure Matrix (JEM)
and to assess the role of subjects’ selection. The initial observed ARp difference was maintained: 36.3% (95% CI: [24.3–50.3]) in study A and 69.7% (95% CI: [51.7–83.2]) in study B. Further investigations
highlighted the potential selection bias introduced in both studies, especially among controls. The ARp could be underestimated in study A and overestimated in study B. After weighting subjects according to distribution of socio-economic
status in the general population for controls and according to distribution of socio-economic status of cases registered by
the French National Mesothelioma Surveillance Program, re-estimated ARp values were 52.4% in study A and 70.2% in study B. These results provide additional information to describe the relationship
between pleural mesothelioma and occupational asbestos exposure, but also confirm the importance of subjects’ recruitment
in case control studies, particularly control selection.
KeywordsAsbestos-Attributable risk-Case–control study-Men-Mesothelioma-Occupational exposure
European Journal of Epidemiology 04/2012; 25(11):799-806. · 4.71 Impact Factor
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Celine Gramond, Patrick Rolland,
Aude Lacourt,
Stephane Ducamp,
Soizick Chamming's,
Yvon Creau,
Michel Hery,
Jacques Laureillard,
Brahim Mohammed-Brahim,
Ewa Orlowski,
Christophe Paris,
Jean-Claude Pairon,
Marcel Goldberg,
Patrick Brochard
[show abstract]
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ABSTRACT: In the course of setting up the National Mesothelioma Surveillance Program (PNSM), established in France in 1998, the question arose as to the most suitable method of assessing occupational exposure. The aim of this study was to define the most suitable rating method for assessing occupational asbestos exposure in order to assess medico-social care.
The study included 100 subjects-50 cases of mesothelioma and 50 controls-randomly selected and representing 457 jobs held. Job asbestos exposure was assessed by a six-expert panel using two methods: "by job" rating, where all the jobs in were assessed regardless of the subjects; and "by subject" rating, where all the jobs of a subject were assessed at the same time. Consensus was obtained and subjects' exposure was calculated for each rating. Then, two internal experts assessed job asbestos exposure with the "by subject" rating. Kappa coefficients were used to measure agreement between the ratings.
Agreement between "by job" and "by subject" ratings was very good for subject probability of exposure (kappa = 0.84) and cumulative exposure index (kappa = 0.80). Agreement between the six-expert panel and the two internal experts was good for subject exposure (kappa for probability = 0.71; kappa for cumulative exposure index= 0.68).
This study shows that the two rating systems have good or very good agreement. These results validate the routine use in the PNSM of the "by subject" rating, with the advantage of being convenient and quick to provide feedback on occupational asbestos exposure to mesothelioma cases for compensation.
American Journal of Industrial Medicine 01/2012; 55(5):440-9. · 1.63 Impact Factor
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Patrick Rolland,
Celine Gramond,
Aude Lacourt,
PhD Philippe Astoul MD,
Soizick Chamming's,
Stephane Ducamp,
Catherine Frenay MD,
Françoise Galateau-Salle MD,
Anabelle Gilg Soit Ilg PhD,
Ellen Imbernon MD,
Nolwenn Le Stang,
PhD Jean Claude Pairon MD,
PhD Marcel Goldberg MD,
Patrick Brochard MD,
for the PNSM Study Group
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ABSTRACT: Background
Occupational exposure to asbestos, widely used in various industries for decades, is the most important risk factor for pleural mesothelioma. We report here the ranking of occupations and industries in France at high risk for this cancer among men and women.MethodsA population-based case–control study, conducted from 1998 to 2002, included 462 cases (80.3% men) and 897 controls. Data were collected in face-to-face interviews with a standardized questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each occupation and industry; subjects never employed in each category were the reference.ResultsFor men, risks were high for several occupations and industries. Besides the expected high risks for non-metallic mineral product makers and manufacturing asbestos products, occupations such as plumbers (OR = 5.57, 95% CI: 2.90–10.69), sheet-metal workers, welders, metal molders, coremakers, and cabinetmakers were also at high risk. Elevated risks were found in the industries of shipbuilding (OR = 9.13, 95% CI: 5.20–16.06) and construction, but also in the manufacturing of metal products, chemicals, and railroad and aircraft equipment. The results for women showed increased but not significant risks in several occupational activities.Conclusions
This report provides new insight into the epidemiology of mesothelioma, confirming risks for occupational activities reported earlier and pointing out risks in activities never previously reported. It offers guidance to authorities for the compensation of asbestos victims and for prevention in at-risk activities still involving asbestos-containing products. Am. J. Ind. Med. 53:1207–1219, 2010. © 2010 Wiley-Liss, Inc.
American Journal of Industrial Medicine 09/2010; 53(12):1207 - 1219. · 1.63 Impact Factor
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Patrick Rolland,
Celine Gramond,
Aude Lacourt,
Philippe Astoul,
Soizick Chamming's,
Stephane Ducamp,
Catherine Frenay,
Françoise Galateau-Salle,
Anabelle Gilg Soit Ilg,
Ellen Imbernon,
Nolwenn Le Stang,
Jean Claude Pairon,
Marcel Goldberg,
Patrick Brochard
[show abstract]
[hide abstract]
ABSTRACT: Occupational exposure to asbestos, widely used in various industries for decades, is the most important risk factor for pleural mesothelioma. We report here the ranking of occupations and industries in France at high risk for this cancer among men and women.
A population-based case-control study, conducted from 1998 to 2002, included 462 cases (80.3% men) and 897 controls. Data were collected in face-to-face interviews with a standardized questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each occupation and industry; subjects never employed in each category were the reference.
For men, risks were high for several occupations and industries. Besides the expected high risks for non-metallic mineral product makers and manufacturing asbestos products, occupations such as plumbers (OR = 5.57, 95% CI: 2.90-10.69), sheet-metal workers, welders, metal molders, coremakers, and cabinetmakers were also at high risk. Elevated risks were found in the industries of shipbuilding (OR = 9.13, 95% CI: 5.20-16.06) and construction, but also in the manufacturing of metal products, chemicals, and railroad and aircraft equipment. The results for women showed increased but not significant risks in several occupational activities.
This report provides new insight into the epidemiology of mesothelioma, confirming risks for occupational activities reported earlier and pointing out risks in activities never previously reported. It offers guidance to authorities for the compensation of asbestos victims and for prevention in at-risk activities still involving asbestos-containing products.
American Journal of Industrial Medicine 09/2010; 53(12):1207-19. · 1.63 Impact Factor
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ABSTRACT: In population-based mesothelioma studies in industrialised countries, the incidence of mesothelioma without any identified asbestos exposure (IAE) is usually higher among women, while male incidence is mainly attributed to IAE. Through a comparison of the spatial distribution of male and female rates, and IAE and no IAE incidence, this study investigated whether mesotheliomas without IAE are in fact induced by non-recognised asbestos exposure, mostly from environmental sources.
We calculated mesothelioma mortality (SMR) and incidence (SIR) ratios by district in France, pooling 30 and 10 years of data, respectively. Using correlation coefficients, we compared geographical patterns of male and female mesothelioma ratios, and IAE and no IAE mesothelioma ratios.
The raw numbers of male and female mesothelioma cases were equivalent. Mesothelioma SMR (0.76) and SIR (0.80) geographical correlations between men and women were strongly positive. SIR correlation between occupationally IAE and no IAE cases was also positive (0.69). Correlation between occupationally IAE and no IAE cases was positive among women but not among men.
Data analyses of mesothelioma mortality and incidence showed that female cases occur in the same geographical areas as male cases. Female mesotheliomas with no IAE occur in the same geographical areas as exposed cases, suggesting asbestos has a major influence on female mesothelioma, likely through environmental exposure.
Occupational and environmental medicine 06/2010; 67(6):417-21. · 3.64 Impact Factor
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Francoise Galateau-Sallé,
Richard Attanoos,
Allen R Gibbs,
Louise Burke,
Philippe Astoul, Patrick Rolland,
Anabelle Gilg Soit Ilg,
Jean Claude Pairon,
Patrick Brochard,
Hugues Begueret,
Jean Michel Vignaud,
Keith Kerr,
Guy Launoy,
Ellen Imbernon,
Marcel Goldberg
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ABSTRACT: The lymphohistiocytoid variant of diffuse malignant mesothelioma is rare with very few cases described in the literature. It is characterized by mesothelial cells with a histiocytelike appearance and an associated dense lymphoid infiltrate. We studied clinicopathologic features and immunohistochemical patterns of a series of 22 cases. The histiocytelike cells had a mesothelial immunophenotype: AE1/AE3 (100%), calretinin (100%), CK5/6 (46%), and EMA (52%). The prominent lymphoid component showed a cytotoxic T-cell immunophenotype. Prognosis was similar to that of a large series of epithelioid diffuse malignant mesotheliomas. Formely, it was classified within the sarcomatoid type. We suggest that it should be reclassified as an epithelioid variant because of its similar behavioural characteristics. There was no evidence of Epstein-Barr virus-related infection.
American Journal of Surgical Pathology 06/2007; 31(5):711-6. · 4.35 Impact Factor
