Panida Hemmati

Publications (3)19.36 Total impact

• Article: Orexin A activates locus coeruleus cell firing and increases arousal in the rat

  Jim J Hagan, Ron A. Leslie, Sara Patel, Martyn L. Evans, Trevor A. Wattam, Steve Holmes, Christopher D. Benham, Stephen G. Taylor, Carol Routledge, Panida Hemmati, [......], Tracey E. Ashmeade, Ajit S. Shah, Jonathan P. Hatcher, Paula D. Hatcher, Declan N C Jones, Martin I Smith, David C. Piper, A Jackie Hunter, Rod A. Porter, Neil Upton
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  ABSTRACT: The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.
  Proceedings of the National Academy of Sciences 10/1999; · 9.68 Impact Factor
• Source

  Available from: Trevor A. Wattam

  Article: Orexin A activates locus coeruleus cell firing and increases arousal in the rat

  Jim J. Hagan, Ron A. Leslie, Sara Patel, Martyn L. Evans, Trevor A. Wattam, Steve Holmes, Christopher D. Benham, Stephen G. Taylor, Carol Routledge, Panida Hemmati, [......], Tracey E. Ashmeade, Ajit S. Shah, Jonathan P. Hatcher, Paula D. Hatcher, Declan N. C. Jones, Martin I. Smith, David C. Piper, A. Jackie Hunter, Rod A. Porter, Neil Upton
  [show abstract] [hide abstract]
  ABSTRACT: The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral techniques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and modulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.
  Proceedings of the National Academy of Sciences 09/1999; 96(19):10911-10916. · 9.68 Impact Factor
• Article: Orexin A activates locus coeruleus cell firing and increases arousal in the rat (immunocytochemistryyhypothalamusysleepylocomotor activityygrooming)

  JIM J. HAGAN, R ON A. LESLIE, SARA PATEL, MARTYN L. EVANS, TREVOR A. WATTAM, S TEVE HOLMES, CHRISTOPHER D. BENHAM, STEPHEN G. TAYLOR, CAROL ROUTLEDGE, PANIDA HEMMATI, RICHARD P. MUNTON, TRACEY E. ASHMEADE
  [show abstract] [hide abstract]
  ABSTRACT: The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothala- mus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modu- lating the arousal state of rats by using a combination of tissue localization and electrophysiological and behavioral tech- niques. We show that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexin A increases cell firing of intrinsic noradrenergic neurones. Orexin A increases arousal and locomotor activity and mod- ulates neuroendocrine function. The data suggest that orexin A plays an important role in orchestrating the sleep-wake cycle.