Panida Asavapichayont

Publications (2)2.86 Total impact

• Article: Pectin-based bioadhesive delivery of carbenoxolone sodium for aphthous ulcers in oral cavity.

  Nathaya Wattanakorn, Panida Asavapichayont, Jurairat Nunthanid, Sontaya Limmatvapirat, Srisagul Sungthongjeen, Doungdaw Chantasart, Pornsak Sriamornsak
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  ABSTRACT: The objective of this study was to prepare and evaluate the pectin-based dosage form for buccal adhesion. Carbenoxolone sodium, which is used for the treatment of aphthous ulcers in oral cavity, was used as a model drug. The pectin buccal discs were prepared by direct compression. The water uptake and erosion of pectin disc increased progressively with the swelling time. The bioadhesion of dried pectin discs decreased when either the discs were hydrated or the buccal tissue was wet with a small volume of medium. The influencing factors such as pectin type, pectin to lactose ratio, and sweetener type on the formulations were investigated. The results demonstrated that buccal discs prepared from pectin with a high degree of esterification (DE) showed a weaker and more friable characteristic than that with low DE. Decreasing pectin to lactose ratio resulted in the high dissolution rate with low bioadhesive properties. Addition of sweetener in the formulations also affected the hardness, friability, and bioadhesive properties of the discs. The pectin discs containing sweetening agent showed a higher drug release than those without sweetener. The results suggested that pectin-based bioadhesive discs could be used to deliver carbenoxolone sodium in oral cavity.
  AAPS PharmSciTech 06/2010; 11(2):743-51. · 1.43 Impact Factor
• Article: Wax-incorporated emulsion gel beads of calcium pectinate for intragastric floating drug delivery.

  Pornsak Sriamornsak, Panida Asavapichayont, Jurairat Nunthanid, Manee Luangtana-Anan, Sontaya Limmatvapirat, Suchada Piriyaprasarth
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  ABSTRACT: The purpose of this study was to prepare wax-incorporated pectin-based emulsion gel beads using a modified emulsion-gelation method. The waxes in pectin-olive oil mixtures containing a model drug, metronidazole, were hot-melted, homogenized and then extruded into calcium chloride solution. The beads formed were separated, washed with distilled water and dried for 12 h. The influence of various types and amounts of wax on floating and drug release behavior of emulsion gel beads of calcium pectinate was investigated. The drug-loaded gel beads were found to float on simulated gastric fluid if the sufficient amount of oil was used. Incorporation of wax into the emulsion gel beads affected the drug release. Water-soluble wax (i.e. polyethylene glycol) increased the drug release while other water-insoluble waxes (i.e. glyceryl monostearate, stearyl alcohol, carnauba wax, spermaceti wax and white wax) significantly retarded the drug release. Different waxes had a slight effect on the drug release. However, the increased amount of incorporated wax in the formulations significantly sustained the drug release while the beads remained floating. The results suggest that wax-incorporated emulsion gel beads could be used as a carrier for intragastric floating drug delivery.
  AAPS PharmSciTech 02/2008; 9(2):571-6. · 1.43 Impact Factor