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ABSTRACT: The antihepatotoxic effects of Xylopia phloiodora extracts were evaluated in experimental models of liver injury in rats induced by CCl<sub>4</sub> or paracetamol. Crude extract (CE), ether extract (EE) and essential oils from stem bark or leaves were tested. Hepatic function was accessed by measuring serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rats. Liver malondialdehyde (MDA) and reduced glutathione were also measured in control and treated rats. X. phloiodora leaves (CE) and stem bark (CE) extracts showed hepatoprotective activities at doses equivalent to 2.5 g of plant/kg, since serum levels of ALT and AST in rats given the extracts were significantly low (p<0.05 and p<0.01, respectively) when compared to control CCl<sub>4</sub>-injured rats. Further studies were carried on the CE from stem bark of X. phloiodora which showed the highest level of protection against hepatitis. Further studies of the crude extract showed highest antihepatotoxic activity with the ether precipitate (PE) which was effective at 100mg/kg for hepatocurative activity in CCl<sub>4</sub>-injured rats. In experiments comparing the PE (100 mg kg<sup>-1</sup>) to a reference antihepatotoxic substance (silymarin) the PE exhibited a 71 and 80% hepatoprotection compared to the 80 and 90% one exhibited by silymarin in CCl<sub>4</sub>-and paracetamol-injured rats respectively. This study demonstrated that ether precipitate of Xylopia phloiodora was effective in protecting the liver from toxic hepatitis.
International Journal of Pharmacology. 01/2007;
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ABSTRACT: The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.
Bioscience Biotechnology and Biochemistry 10/2005; 69(9):1763-6. · 1.28 Impact Factor
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ABSTRACT: Xanthones are a class of heterocyclic compounds containing oxygen, with a yellow coloration and all of them have dibenzo-γ-pyrone as the basic skeleton. A number of this class of compounds has been isolated from a variety of natural sources (higher plants, fungi and lichens). They have gradually risen to great importance because of their many interesting pharmacological and biological properties.
Advances in Phytomedicine. 2:273-298.
