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Publications (3)0 Total impact

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    ABSTRACT: To evaluate the usefulness of diffusion-weighted MRI sequences and of the apparent diffusion coefficient (ADC) to differentiate between benign and malignant breast lesions. We prospectively studied 88 patients (aged 31 to 79 years) with 94 lesions (80 malignant and 14 benign) who were referred for preoperative local staging. All patients underwent dynamic MRI examination after intravenous contrast administration and a diffusion-weighted sequence with ADC calculation. The results obtained at diffusion-weighted imaging were correlated with those obtained at histological examination. The mean value of the ADC for malignant lesions (1.12+/-0.25x10(-3)mm(2)/s) was significantly lower (p<0.001) than for benign lesions (1.61+/-0.52x10(-3)mm(2)/s). No significant differences in ADC values were found between the different subtypes of invasive carcinomas or between intraductal carcinoma and invasive carcinoma (p>0.05). Using an ADC lower than 0.95x10(-3)mm(2)/s as a threshold for malignancy, the sensitivity is 52% and the specificity is 100%. Diffusion-weighted sequences provide additional information in breast MRI that is useful for differentiating between benign and malignant lesions, thus improving the specificity of the technique.
    Radiología 07/2009; 51(5):469-76.
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    ABSTRACT: Objective To evaluate the usefulness of diffusion-weighted MRI sequences and of the apparent diffusion coefficient (ADC) to differentiate between benign and malignant breast lesions.
    Radiología. 01/2009; 51(5).
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    ABSTRACT: Objective To evaluate the efficacy of a magnetic resonance imaging technique of the breast using half-field equipment (0.5 T). Material and method We evaluated 191 magnetic resonance (MRI) studies made at our center from March 1998 to March 2001 using Signa Contour 0.5 T MRI equipment of General Electric. A dedicated bilateral breast coil was used. Fast-echo T1-weighted 3D gradient sequences were made at fat saturation in the coronal plane before administering intravenous gadolinium, then 6 consecutive times after contrast administration. The sequence acquisition time was 70-90 seconds. Image post-processing included subtraction and analysis of the intensity/time curves in the region of interest (ROI) together with morphological evaluation of the lesion. Additional T2-weighted fast-spin-echo sequences (FSE T2), T1-weighted spin-echo (SE T1), FSE T2 with fat suppression, and STIR with water saturation were made for studies of breast implants. Results The clinical indications for MRI study of the breast were masses (n = 79), microcalcifications (n = 7), assymmetry (n = 17), cases of indeterminate risk (n = 7), postoperative control (n = 51), and breast implants (n = 25). The histological diagnosis was benign in 31 lesions and malignant in 73 lesions. The sensitivity, specificity, and reliability of breast MRI were 93%, 81%, and 89%, respectively. Multi-center/multifocal neoplasms were found in 8% of patients and bilateral neoplasms in 2%. The therapeutic attitude was modified in 18% of the patients with breast cancer as a result of MRI findings. Conclusions The results confirm the usefulness of MRI in the management of patients with breast cancer. Likewise, the present study demonstrates that breast MRI can be carried out with half-field equipment with the same reliability as with full-field equipment as long as specific breast coils are used, rapid 3D sequences, and image processing with suitable software.
    Radiología. 44(5):187–193.