Monica Masotti

Publications (7)26.45 Total impact

• Article: One-year head to head comparison of the neointimal response between sirolimus eluting stent with reservoir technology and everolimus eluting stent. An optical coherence tomography study.

  Yoshitaka Shiratori, Salvatore Brugaletta, Luis Alvarez-Contreras, Yajaziel Azpeitia, Nestor Ospino, Sebastian Gaido, Anuar Delahanty, Alejandro Santos, Victoria Martin-Yuste, Monica Masotti, Patrick W Serruys, Stephan Windecker, Manel Sabaté
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  ABSTRACT: Objective: to compare the vascular healing process between the sirolimus-eluting NEVO and the everolimus-eluting Xience stent by optical coherence tomography (OCT) at 1-year follow-up. Background: Presence of durable polymer on a drug-eluting metallic stent may be the basis of an inflammatory reaction with abnormal healing response. The NEVO stent, having a bioresorbable polymer eluted by reservoir technology, may overcome this problem. Methods: All consecutive patients, who received NEVO or Xience stent implantation between September 2010 and October 2010 in our institution, were included. Vascular healing was assessed at 1-year as percentage of uncovered struts, neointimal thickness, in-stent / stent area obstruction and pattern of neointima. Results: A total 47 patients (2:1 randomization, n=32 NEVO, n=15 Xience) were included. Eighteen patients underwent angiographic follow-up (8 patients with 9 lesions for NEVO vs. 10 patients with 11 lesions for Xience). The angiographic late loss was numerically higher but not statistically different in NEVO compared with Xience treated lesions (0.38 ± 0.47 mm vs. 0.18 ± 0.27 mm; p=0.171). OCT analysis of 4912 struts demonstrated similar rates of uncovered struts (0.5% vs. 0.7%, p=0.462), higher mean neointimal thickness (177.76 ± 87.76 µm vs. 132.22 ± 30.91 µm; p=0.170) and in stent / stent area obstruction (23.02 ± 14.74% vs. 14.17 ± 5.94%, p=0.120) in the NEVO as compared with Xience. Conclusion: The NEVO stent with a reservoir technology seems to exhibit more neointimal proliferation as compared to Xience stent. The findings of our study, which currently represent the unique data existing on this reservoir technology, would need to be confirmed in a large population. © 2013 Wiley Periodicals, Inc.
  Catheterization and Cardiovascular Interventions 02/2013; · 2.29 Impact Factor
• Article: Endothelial function in coronary chronic total occlusions: need for rigorous methodology.

  Salvatore Brugaletta, Victoria Martin-Yuste, Monica Masotti, Josep Gomez-Lara, Hector M Garcia-Garcia, Patrick W Serruys, Manel Sabaté
  Journal of the American College of Cardiology 08/2012; 60(9):871-2; author reply 872-3. · 14.16 Impact Factor
• Article: Isolated right ventricular infarction presenting with anterior ST-segment elevation: a case for careful assessment of right ventricular branch occlusion.

  Sérgio Nabais, Victoria Martin-Yuste, Monica Masotti, Manel Sabaté
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  ABSTRACT: We describe the case of a 61-year-old man who presented with chest pain and ST-segment elevation in the anterior precordial leads (V1-V5) due to proximal occlusion of the right ventricular branch of a codominant right coronary artery. Primary coronary angioplasty and stenting of this branch was performed resulting in resolution of the chest pain and ST-segment elevation. Our description illustrates a case of isolated right ventricular infarction as an uncommon but important differential diagnosis of anterior ST-segment elevation. In addition, it highlights the value of careful review of the angiographic images in this context, as the culprit lesion may be a right ventricular branch occlusion. To the best of our knowledge, this is the first reported case of primary percutaneous coronary intervention treatment of a right ventricular branch occlusion causing isolated acute right ventricular myocardial infarction and anterior ST-segment elevation.
  Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 03/2012; 31(4):301-4.
• Article: Endothelial and smooth muscle cells dysfunction distal to recanalized chronic total coronary occlusions and the relationship with the collateral connection grade.

  Salvatore Brugaletta, Victoria Martin-Yuste, Teresa Padró, Luis Alvarez-Contreras, Josep Gomez-Lara, Hector M Garcia-Garcia, Clarissa Cola, Giovanna Liuzzo, Monica Masotti, Filippo Crea, Lina Badimon, Patrick W Serruys, Manel Sabaté
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  ABSTRACT: This study sought to assess the vascular function in patients with chronic total coronary occlusions (CTO) immediately after successful percutaneous recanalization and its relation with the pre-existing collateral circulation. CTOs represent a long-acting occlusion of a coronary vessel, in which the progressively developed collateral circulation may limit ischemia and symptoms. However, it is unknown if the coronary segment distal to the occlusion has a preserved vascular function. We prospectively enrolled 19 consecutive patients, after percutaneous coronary intervention of a CTO. Luminal diameter, measured by quantitative coronary angiography, and coronary blood flow at level of epicardial coronary artery distal to the treated CTO was assessed before and after administration of acetylcholine (Ach), adenosine, and nitroglycerin (NTG). Collaterals were assessed angiographically by grading of Rentrop and of collateral connections (CC1: threadlike continuous connection; CC2: side branch-like connection). Overall, Ach and adenosine caused coronary artery vasoconstriction (p=0.001 and p=0.004, respectively), whereas NTG failed to induce vasodilation (p=0.084). Coronary blood flow significantly decreased with Ach (p=0.005), significantly increased with NTG (p=0.035), and did not change with adenosine (p=0.470). Patients with CC2 collaterals (n=8) had less vasoconstriction response and reduction in coronary blood flow after Ach (p=0.005 and p=0.008, respectively), and better vasomotor response to NTG (p=0.029) than patients with CC1 collaterals (n=11). Significant endothelial and smooth muscle dysfunction is present in the distal segments of successfully recanalized CTOs, and that seems to be more pronounced in the presence of a low grading of collateral circulation.
  02/2012; 5(2):170-8. · 1.07 Impact Factor
• Article: Endothelin-1 levels predict endothelial progenitor cell mobilization after acute myocardial infarction.

  Xavier Freixa, Monica Masotti, Marta Palomo, Maribel Diaz-Ricart, Ginés Escolar, Eduard Guasch, Ander Regueiro, Marcelo Jiménez, Amadeo Betriu, Magda Heras
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  ABSTRACT: Endothelin-1 (ET-1), circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) are well-known modulators of endothelial function with important cardiac effects after an acute myocardial infarction. However, the relationship between them has never been assessed. The objective of the present study was to establish the relationship between ET-1, CEC, and EPC concentrations after ST-elevation myocardial infarction (STEMI). Endothelin-1, CEC, and EPC levels were measured in 61 patients presenting with a first STEMI. Samples were withdrawn acutely 6-24h and 1week after admission. Assessments included reperfusion outcomes (angiography), left ventricular ejection fraction (echocardiography), and 30-day mortality. Mean age was 60.6±12.6years and 45 (74%) were males. Higher ET-1 plasma levels were associated with lower EPC count after 1week (7.45±2.53pg/ml if EPCs in the first quartile vs 5.72±1.49pg/ml if EPCs in the fourth quartile; P=0.04). In contrast with CEC and EPC count, higher ET-1 concentrations on admission were associated with Killip≥2 (9.92±2.01pg/ml vs 7.32±2.13pg/ml; P<0.001), post-reperfusion thrombolysis in myocardial infarction (TIMI) <3 (8.65±2.86pg/ml vs 5.87±1.93pg/ml; P=0.002), myocardial blush grade (MBG) <3 (7.46±2.48pg/ml vs 5.99±2.01pg/ml; P=0.004) and higher 30-day mortality (10.29±2.02pg/ml vs 6.57±2.20pg/ml; P=0.005). In STEMI patients, high ET-1 levels on admission predict a lower EPC mobilization after 1week. Endothelin-1 provides better clinical, angiographic and echocardiographic information for prognosis than do CEC and EPC concentrations.
  Microvascular Research 09/2011; 82(2):177-81. · 2.83 Impact Factor
• Source

  Available from: Manel Sabaté

  Article: [Usefulness of the Tornus® catheter in nondilatable coronary chronic total occlusion].

  Victoria Martín-Yuste, Luis Alvarez-Contreras, Clarissa Cola, Salvatore Brugaletta, Juan García Picart, Vicens Martí, Monica Masotti, Manel Sabaté
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  ABSTRACT: The treatment of coronary chronic total occlusions (CTO) remains a challenge for the interventional cardiologist. Failure of balloon angioplasty is the second more common cause of an unsuccessful procedure. We describe our experience with the use of the new Tornus® catheter (Asahi Intecc, Aichi, Japan) designed specifically for the treatment of "nondilatable" CTO. Between November 2008 and March 2010, 17 patients (age 62 years, 88% men, 82% dyslipidemia, 52% hypertension, 29% diabetes) were treated in whom balloon dilatation had failed after crossing the lesion with the guide. The use of Tornus® catheter was successful without complications in 15. All patients underwent clinical follow-up (median, 573 days) with no documented major adverse events. The use of the Tornus® catheter is safe and feasible in those patients with CTO lesions in whom balloon angioplasty has been unsuccessful.
  Revista Espa de Cardiologia 06/2011; 64(10):935-8. · 2.53 Impact Factor
• Article: Early risk stratification of patients with cardiogenic shock complicating acute myocardial infarction who undergo percutaneous coronary intervention.

  Ana Garcia-Alvarez, Dabit Arzamendi, Pablo Loma-Osorio, Ricardo Kiamco, Monica Masotti, Alessandro Sionis, Amadeo Betriu, Josep Brugada, Xavier Bosch
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  ABSTRACT: The mortality rate of patients with cardiogenic shock complicating acute myocardial infarction remains exceedingly high despite early mechanical revascularization. Early risk stratification is of great importance to identify patients who could benefit from ventricular assist devices and urgent heart transplantation (UHT). All consecutive patients with cardiogenic shock complicating acute myocardial infarction admitted from June 2001 to December 2007 were prospectively included. Clinical, hemodynamic, and echocardiographic variables were registered on admission and patients were followed for a median of 297 days. A total of 74 patients were included. One-year mortality was 55% and 7 patients (9%) underwent UHT. One-year mortality or need for UHT for patients with postprocedural Thrombolysis In Myocardial Infarction (TIMI) grade 3, 2, and 0 or 1 flows were 38%, 92%, and 90%, respectively (p <0.001). After adjustment by multivariate analysis, the most important predictors of mortality or need for UHT were age >75 years (hazard ratio [HR] 3.56, 95% confidence interval [CI] 1.07 to 11.80), left main coronary artery occlusion (HR 3.75, 95% CI 1.09 to 12.84), left ventricular ejection fraction <25% (HR 2.70, 95% CI 1.17 to 6.22), and postprocedural TIMI grade <3 flow (HR 3.37, 95% CI 1.48 to 7.72). A simple risk score constructed with these 4 variables effectively predicted 1-year survival without the need for UHT (83% for score 0, 19% for score 1, and 6% for score 2, p <0.001). In conclusion, age >75 years, left main coronary artery occlusion, left ventricular ejection fraction <25%, and postprocedural TIMI grade <3 flow were significantly associated with worse prognosis. A simple risk score rapidly available in the catheterization laboratory can efficiently estimate prognosis.
  The American journal of cardiology 04/2009; 103(8):1073-7. · 3.58 Impact Factor