Misato Fujii

Publications (2)2.82 Total impact

• Article: Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

  Toshifumi Hirata, Misato Fujii, Kazuhiro Akita, Noriyuki Yanaka, Kaori Ogawa, Masanori Kuroyanagi, Daiki Hongo
  [show abstract] [hide abstract]
  ABSTRACT: On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone had the greatest anti-corpulence effects and 3,5,6,7,8,3',5'-heptamethoxyflavone had the greatest anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses.
  Bioorganic & medicinal chemistry 12/2008; 17(1):25-8. · 2.82 Impact Factor
• Article: Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer

  Toshifumi Hirata, Misato Fujii, Kazuhiro Akita, Noriyuki Yanaka, Kaori Ogawa, Masanori Kuroyanagi, Daiki Hongo, トシフミ ヒラタ, ミサト フジイ, Misato Fujī, [......], マサノリ クロヤナギ, ダイキ ホンゴウ, Daiki Hongō, 敏文 平田, 美里 藤井, 和大 明田, 規之 矢中, 佳織 小川, 正典 黒柳, 大樹 本郷
  [show abstract] [hide abstract]
  ABSTRACT: On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3′,4′-pentamethoxyflavone had the greatest anti-corpulence effects and 3,5,6,7,8,3′,5′-heptamethoxyflavone had the greatest anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses.