Mirjana Vojinovic-Miloradov

University of Novi Sad, Varadinum Petri, Autonomna Pokrajina Vojvodina, Serbia

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Publications (18)21.25 Total impact

  • Sanja Mrazovac, Mirjana Vojinović-Miloradov, Ivan Matić, Nenad Marić
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    ABSTRACT: The geothermal waters of the Province of Vojvodina in northern Serbia, south part of the Pannonian Basin, are characterized by temperatures between 24 and 75 °C. Dominant ions in these waters are sodium and bicarbonate, but the waters also contain significant amounts of calcium, magnesium, potassium, chlorides, and ammonium. Components that are of balneological significance include iodine, bromine, fluorine, strontium, lithium and barium, metasilicic and metaboric acids. Reported are the physicochemical parameters of this groundwater drilled from 200 to 1200 m depth in Vojvodina's territory.Hydrogeochemical studies were carried out in this area with the objective of identifying the geochemical processes and their relation to groundwater quality. Weathering of silicate minerals controls the concentration of major ions such as sodium, calcium, magnesium and potassium in the groundwater of this area. The reverse ion exchange process controls the concentration of calcium, magnesium and sodium in hard rock formations, and dissolution of carbonate minerals and accessory minerals is the source of Ca and Mg, in addition to cation exchange in the sedimentary formations. In general, the chemical composition of the groundwater in this area is influenced by rock–water interaction, dissolution and deposition of carbonate and silicate minerals and ion exchange.An attempt has been made to study quality of groundwater using multivariate statistical technique such as cluster analyses. Hydrogeochemical data for 13 groundwater samples were subjected to correlation and R- and Q-mode cluster analysis, where R-mode analysis reveals the inter-relations among the variables studied, and Q-mode analysis reveals the inter-relations among the samples studied.
    Chemie der Erde - Geochemistry 06/2013; 73(2):217–225. · 1.35 Impact Factor
  • Sanja M. Mrazovac, Pantic R. Milan, Mirjana B. Vojinovic-Miloradov, Bratislav S. Tosic
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    ABSTRACT: This paper presents a mathematical model to describe the time evolution of the diffusion process of methane exchange between liquid and gaseous phases. In order to reach the equilibrium, the distribution of gas in the liquid phase decreases to a constant value over time. Generalized model is analyzed under the assumption that both, reversible and irreversible form of absorption and desorption, occur at the same time. For the application in case of the real system of methane–water, model is developed under the assumption that the processes of absorption and desorption are irreversible. From the experimental data are determined the coefficients of model and their dependence on initial conditions, with constant end conditions. This paper tests the introduced theoretical model on the existing experimental data.
    Applied Mathematical Modelling 09/2012; 36(9):3985–3991. · 2.16 Impact Factor
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    ABSTRACT: In order to examine the antioxidant properties of five different extracts of Trifolium pratense L. (Leguminosae) leaves, various assays which measure free radical scavenging ability were carried out: 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, superoxide anion and nitric oxide radical scavenger capacity tests and lipid peroxidation assay. In all of the tests, only the H<sub>2</sub>O and (to some extent) the EtOAc extracts showed a potent antioxidant effect compared with BHT and BHA, well-known synthetic antioxidants. In addition, in vivo experiments were conducted with antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx) in liver homogenate and blood of mice after their treatment with extracts of T. pratense leaves, or in combination with CCl<sub>4</sub>. Besides, in the extracts examined the total phenolic and flavonoid amounts were also determined, together with presence of the selected flavonoids: quercetin, luteolin, apigenin, naringenin and kaempferol, which were studied using a HPLC-DAD technique. HPLC-DAD analysis showed a noticeable content of natural products according to which the examined Trifolium pratense species could well be regarded as a promising new source of bioactive natural compounds, which can be used both as a food supplement and a remedy.
    Molecules 01/2012; 17(9):11156-72. · 2.43 Impact Factor
  • Sanja Mrazovac, Mirjana Vojinović-Miloradov
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    ABSTRACT: The geothermal waters of the first and the shallowest groundwater system of the Province of Vojvodina in northern Serbia, south part of the Pannonian Basin, are characterized by elevated temperatures (between 25 and 85°C) and elevated gas content (above 1Nm3/m3) with a high methane content (average about 94% of total gases). These methane-containing waters are particularly abundant in the Central part of the province between Danube and Tisa rivers. Dominant ions in these waters are sodium and bicarbonate, but the waters also contain significant amounts of calcium, magnesium, potassium, chloride, and ammonium. Components that are of balneological significance include iodine, bromine, fluorine, strontium, lithium, barium, and metasilicic and metaboric acids. Based on statistical analysis, a strong positive correlation is generally observed in about 9.2% cases. A slightly lower correlation appears in about 42.2%, and negative correlation coefficient appears in about 48.6% cases. The dendrogram of the cluster analysis built on the wells shows three main groups. There is the cluster of (Na+)aq, (Cl−)aq and (HCO3−)aq. The second aggregation is (NH4+)aq/(NH3)aq. The third group includes (Mg2+)aq, (Ca2+)aq, (Fe3+)aq, (Sr2+)aq, (Pb2+)aq, and (Zn2+)aq.
    Fuel and Energy Abstracts 01/2011; 108(3):176-182.
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    ABSTRACT: Combinatorial bio/chemical approach was applied to investigate dioxin-like contamination of soil and sediment at the petrochemical and organochlorine plant in Pancevo, Serbia, after the destruction of manufacturing facilities that occurred in the spring of 1999 and subsequent remediation actions. Soil samples were analyzed for indicator polychlorinated biphenyls (PCBs) by gas chromatography/electron capture detection (GC/ECD). Prioritized soil sample and sediment samples from the waste water channel were analyzed for polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) by high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Microethoxyresorufin o-deethylase (Micro-EROD) and H4IIE-luciferase bioassays were used for monitoring of dioxin-like compounds (DLC) and for better characterization of dioxin-like activity of soil samples. Bioanalytical results indicated high dioxin-like activity in one localized soil sample, while the chemical analysis confirmed the presence of large quantities of DLC: 3.0 × 10(5) ng/g d.w. of seven-key PCBs, 8.2 ng/g d.w. of PCDD/Fs, and 3.0 × 10(5) ng/g d.w. of planar and mono-ortho PCBs. In the sediment, contaminant concentrations were in the range 2-8 ng/g d.w. of PCDD/Fs and 9-20 ng/g d.w. of PCBs. This study demonstrates the utility of combined application of bioassays and instrumental analysis, especially for developing and transition country which do not have capacity of the expensive instrumental analysis. The results indicate the high contamination of soil in the area of petrochemical plant, and PCDD/Fs contamination of the sediment from the waste water channel originating from the ethylene dichloride production.
    Environmental Science and Pollution Research 11/2010; 18(4):677-86. · 2.76 Impact Factor
  • TEMPUS Project SM_SCM-C037B06-2006 01/2008: pages 107-116; University of Novi Sad, Faculty of Technical Sciences.
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    ABSTRACT: New non-covalent intermolecular fullerene system containing discrete C 60 and alcohol molecules have been prepared from the saturated solutions of fullerene in toluene with ethanol, methanol and isopropanol. The formation of intercalates with alcohols R-OH , C 60 (R ˆ C 1 -C 3) has not been described in the literature yet. Pure intercalates R-OH , C 60 were obtained in the direct synthesis of C 60 in toluene with R-OH (methanol, ethanol and isopropanol). UV and IR spectra of C 2 H 5 -OH , C 60 and C 3 H 7 -OH , C 60 showed no change compared to the pristine C 60 . However, IR spectrum of the methanol intercalate contains additional peaks at 2920 and 3400 cm 21 . There has also been no change in their diffraction images concerning the d-values (the diffractograms of powder), indicating that the compounds are isostructural with C 60 . The appearance of a very intensive d 101 peak in the powder diffractogram of the methanol derivative indicates that stacking disorder is probably eliminated, which can be correlated to the additional bands in IR spectrum. Intermolecular interactions (of the type that exists in supramolecular systems) between C 60 and alcohol molecules C 1 -C 3 exist because of the speci®c energy surfaces of C 60 molecule (the consequence of its electronic, vibrational and rotational properties) and the size, inductive, spatial and geometrical characteristics of intercalants (alcohols). The size and shape of the alcohols which form intercalates with C 60 is such that they nicely ®t within the intermolecular distances of C 60 molecules (0.293 nm) in a hexagonal lattice. q 1998 Elsevier Science B.V. All rights reserved
    Journal of Molecular Structure 01/2008; 471(1). · 1.40 Impact Factor
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    ABSTRACT: In this study level of soil contamination by polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in two oil refineries in Vojvodina region of Serbia was assessed using combined bio/chemical approach. Toxicity of the samples, determined by microEROD analysis, could not be exclusively attributed to the content of measured PCBs and PAHs, but also to the presence of unknown dioxin-like compounds (DLC), and/or positive interactions among similarly acting chemicals. The results proved that biotests, when applied in ecotoxicological assessments, should be used either as a screening tool or initial step in effect-directed analyses.
    Bulletin of Environmental Contamination and Toxicology 11/2007; 79(4):422-6. · 1.11 Impact Factor
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    ABSTRACT: The antioxidant properties of open cage water-soluble fullerenol C60(OH)24 were tested by measuring their ability to scavenge stable 2,2-diphenyl-1-picryl¬hy¬dra¬zyl (DPPH) free radical and reactive hydroxyl radical (∙OH) during the Fenton reaction using electron spin resonance (ESR) spectroscopy. The fullerenol, obtained by newly developed method in our laboratory, scavenged bouth type of investigated radicals in dose-dependent manner in concentration range of 0.18-0.88 mmol/l. Generally, higher concentrations (0.71-0.88 mmol/l) of fullerenol possessed better inhibition of hydroxyl radical (50-82%) than of DPPH radical (28-50%). Fullerenol can exhibit its antioxidative properties by simultaneous hydrogen atom donation to investigated free radicals (DPPH and ∙OH). This reaction also gave rise to the generation of the fullerenol radical C60(OH)23O. which presence was confirmed by ESR. Interaction between hydroxyl radical and fullerenol also based on radical-addition reaction of 2n .OH radicals to remaining olefinic double bonds of fullerenol core to yield C60(OH)24+2n.OH (n=1-12).
    Oxidation Communications 06/2005; 27(4):549-554. · 0.15 Impact Factor
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    ABSTRACT: Paper presents the effects of the newly synthesized fullerol C60(OH)22 on the growth of tumor cells in vitro and its modulating activity on doxorubicin (DOX)-induced cytotoxicity in human breast cancer cell lines. Cell growth inhibition was evaluated by tetrazolium colorimetric WST1 assay. Electron spin resonance (ESR) "trapping" method was used to investigate OH-radical scavenger activity of fullerol during Fenton's reaction. At a range of nanomolar concentrations fullerol induced cell growth inhibition, which was cell line, dose and time dependent. Fullerol also strongly suppressed DOX-induced cytotoxicity at all concentrations regardless the time of fullerol addition. Proanthocyanidins added as single agent to MCF-7 cell culture for 48 h induced low growth inhibition but in combination with DOX strongly decreased DOX cytotoxicity. Fullerol was found to be a potent hydroxyl radical scavenger: the relative intensity of ESR signals of DMPO-hydroxyl radical (DMPO-OH) spin adduct decreased by 88% in the presence of 0.5 microg/ml of fullerol. The obtained results suggest that antiproliferative effect of the fullerol and its protective effect on DOX-induced cytotoxicity might be mediated through hydroxyl-radical scavenger activity of C60(OH)22.
    Toxicology in Vitro 11/2004; 18(5):629-37. · 2.65 Impact Factor
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    ABSTRACT: Investigation of the possible nitric oxide-scavenging activity of hydroxylated derivative of fullerene, fullerenol C60(OH)24, demonstrated that it expressed direct scavenging activity toward nitric oxide radical (NO) liberated within solution of sodium nitroprusside (SNP), a well known NO donor. In parallel, pre-treatment (30') with intratesticular injection of fullerenol (60 microg/each testis) prevented NO-induced decrease of catalase, glutathione transferase and glutathione peroxidase activities in the denucleated fraction of interstitial testicular cells of adult rats 2 h after intratesticular injection of SNP (20 microg/each testis). In addition, fullerenol decreased formation of thiobarbituric acid-reactive substances (TBA-RS) with similar efficiency as butylated hydroxy toluen (BHT), a well known antioxidant. Also, fullerenol expressed certain scavenging activity toward superoxide anion (O2-) in xanthine/xanthine oxidase system. In summary, results obtained in this study confirmed free radical-scavenging activity of fullerenol, and according to our knowledge, it is the first evidence of direct NO-quenching activity of hydroxylated C60 derivative in different milieu.
    Nitric Oxide 10/2004; 11(2):201-7. · 3.27 Impact Factor
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    Materials Science Forum - MATER SCI FORUM. 01/2004;
  • Aleksandar N. Djordjevic, Mirjana B. Vojinovic-Miloradov, Gordana M. Bogdanovic
    ChemInform 01/2003; 34(5).
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    ABSTRACT: In this paper the procedure for catalytical bromination of C 60 with elementary bromine with FeBr 3 as a catalyst is described In this procedures only one reaction product - C 60 Br 24 is obtained. The twenty four bromine atoms are symmetrically distributed over the C 60 sphere, which was confirmed by thermogravi metric analysis. The yield of bromine derivative in this reaction is 98%.
    Fullerene Science and Technology 01/1998; 6(4):689.
  • J. Adamov, M. Vojinović-Miloradov
    Materials Science Forum - MATER SCI FORUM. 01/1998;
  • Janos Krizan, Mirjana Vojinovic-Miloradov
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    ABSTRACT: Yugoslavia's exposure to UN sanctions since 1992 resulted in a production reduction in almost every field of economic activity, and that caused a decrease of pollutant inputs in the water ecosystems. Although the boundary profiles of international rivers registered no change, an improvement was detected in river water quality on profiles that run deeper inside the country. The quality of Yugoslav rivers in period from 1991 to 1995 is presented in this paper. The quality of the Danube, Tisa, Sava, Drina, Morava, Ibar, Bojana and Moraca is evaluated by the concentrations of characteristic parameters. The specific situation where the reduction in industrial and agricultural production occurred, together with reduced traffic activities and uncontrolled black-market import of fertilizers, influence the changes in concentrations of water quality parameters. It is possible to conclude, based on analysed data, that a general improvement in the quality of Yugoslav rivers has occurred during the period of observation, 1991–1995.
    Water Research. 01/1997; 31(11):2914-2917.
  • R Kovacević, M Vojinović-Miloradov, I Teodorović, S Andrić
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    ABSTRACT: The effects of PCBs (mixture of 2, 3, 4, 5-tetra; 2, 2', 4, 5, 5'-penta; 2, 2', 3, 3', 6, 6'-hexa and 2, 2', 3, 3', 4, 4', 5, 5'-octa congeners) on androgen production were investigated by suspension of Leydig cells from adult rat testis. hCG-stimulated androgen production was significantly inhibited by PCBs while progesterone level was not affected. Progesterone supported testosterone production was also decreased by PCBs, while conversion of androstenedione to testosterone was unchanged. These results suggest that the activity of microsomal enzyme C21 side-chain cleavage P450 was decreased by PCB treatment of Leydig cells in vitro.
    The Journal of Steroid Biochemistry and Molecular Biology 07/1995; 52(6):595-7. · 3.98 Impact Factor
  • Jasna Adamov, Jan Sudji, Mirjana Vojinovic-Miloradov, Zivka Eri, Ferenc Gaál
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    ABSTRACT: In this paper the content of polychlorinated biphenyls (PCBs) was determined in the samples of human adipose tissue and liver, collected during obductions from random donors of both gender and different ages. Residues of PCBs were determined by GC/ECD. Concentration of total PCBs was in the range 21.9 to 205.8 ng/g of adipose tissue and 3.6 to 47.8 ng/g of liver. The most abundant were congeners PCB 138, PCB 153 and PCB 180, comprising >80% of the total content of PCBs in the adipose tissue and liver. There is no significant correlation between age and gender of the donors and the levels of PCBs in their tissue.

Publication Stats

187 Citations
21.25 Total Impact Points

Institutions

  • 1997–2013
    • University of Novi Sad
      • • Faculty of Technical Sciences
      • • Department of Chemistry, Biochemistry and Environmental Protection
      • • Faculty of Sciences
      Varadinum Petri, Autonomna Pokrajina Vojvodina, Serbia