M A Gonultas

Ankara Atatürk Training and Research Hospital, Engüri, Ankara, Turkey

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Publications (5)4.18 Total impact

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    ABSTRACT: ackground:This experimental study compared the hemostatic effects of calcium alginate and Anka-ferd Blood Stopper in hepatic parenchymal bleedings. The study comprised 39 male Wistar albino rats (weight 230±30 g). Laceration model was created in the left lateral lobe of the liver. Standard cotton gauze that was impregnated 0.9% NaCl solution and Calcium alginate cover was compared to ABS tampon. The amount of preoperative bleeding, preoperative and postoperative Day 1 hematocrit levels, and the difference between them were assessed and statistically analyzed. Comparing the hematocrit levels between the groups, we found that the amount of bleeding was significantly higher in the control group versus the study groups (p<0.001). Histopathological examination revealed the portal area enlargement and biliary canaliculi proliferation. In the Ca2+ Alginate group, it was observed that the fibres were still present in the incision line with massive fibrotic area around. In the Ankaferd group, examination of the preparations revealed patchy focal necrosis areas but no fibrotic area. With this study, we demonstrated that both calcium alginate and Ankaferd have hemostatic effect in preventing hepatic parenchymal bleeding and that calcium alginate causes fibrosis in the liver, where ABS causes focal necrosis areas(Tab. 2, Fig. 4, Ref. 19). Ca2+ alginate, ankaferd blood stopper, liver injuries.
    Bratislavske lekarske listy 01/2015; 116(2):128-31. DOI:10.4149/BLL_2015_025 · 0.45 Impact Factor
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    ABSTRACT: Eugenol an essential oil found in clove was previously shown to have some anti-inflammatory properties. It also was shown to be linked to hepatoprotective effect. In this regard, we aimed to reveal the effect of eugenol on cholestatic liver disease. Cholestatic liver disease model was established in 20 rats via bile duct ligation. Eugenol was administered and cytokine levels and liver histology after sacrifice were evaluated. Biliary ductular proliferation and neutropil infiltration were lower in eugenol-administered rats. Eugenol has a promising effect on liver histology in cholestatic liver disease (Tab. 1, Fig. 2, Ref. 16). biliary ductular proliferation, cholestatic liver disease, bile duct ligation, liver histology, acute cholestasis.
    Bratislavske lekarske listy 01/2014; 115(10):622-4. DOI:10.4149/BLL_2014_120 · 0.45 Impact Factor
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    ABSTRACT: The present study aimed to evaluate intra-abdominal adhesion generating potential of Ankaferd Blood Stopper (ABS), which was used as postoperative hemostatic agent in the rats that underwent surgery, in comparison with Ca-alginate.
    Bratislavske lekarske listy 01/2014; 115(9):544-9. DOI:10.4149/BLL_2014_105 · 0.45 Impact Factor
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    ABSTRACT: Aim: Our goal was to determine the effects of a diosmine-hesperidine combination on wound healing in a rat model of colonic anastomosis.Materials and methods: In this study, 20 Wistar Albino female rats were randomized into four experimental groups containing five rats in each group. A segment of 1 cm of colon was excised 4 cm proximally to the peritoneal reflection in all rats without carrying out any mechanical or antibacterial bowel preparation. Colonic anastomosis was performed with interrupted, inverting sutures of 6/0 polypropylene. Beginning from the first postoperative day, the rats in Groups II and IV received 100 mg/kg per day of diosmine-hesperidine via orogastic route by 4F fine feeding catheter. Results: A significant difference was detected between groups in terms of their hydroxyproline levels (p<0.05); the hydroxyproline level of Group I was significantly lower than that of the other groups while no significant difference was noted between Groups II and III. Conclusion: The administration of diosmine-hesperidine increased the amount of collagen and bursting pressures at the anastomotic site and thus had favorable influences on the healing of colonic anastomosis (Tab. 1, Fig. 3, Ref. 33). Keywords: diosmine-hesperidine, colonic anastomosis.
    Bratislavske lekarske listy 01/2012; 113(12):692-7. DOI:10.4149/BLL_2012_157 · 0.45 Impact Factor
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    ABSTRACT: In the present study, attempts have been made to determine the effects of honey on intestinal morphology, postoperative adhesions, and the healing of colonic anastomoses in the rats after colonic resection and anastomosis. Thirty-six rats were randomly divided into three groups each including 12 animals. Colonic resection and anastomosis were performed on all animals. Rats were fed with standard rat chow in group I, standard rat chow plus 10 g/kg/day honey in group II and artificial honey including the same caloric amount with honey in group III. Adhesion scores, bursting pressures and histopathological examinations were evaluated. Colonic bursting pressures of honey group were significantly better than control and artificial honey groups. Histological analysis of anastomotic site showed that submucosa and muscularis propria were nearly filled with granulation tissue and regular fibrin matrix in honey group. There was statistically significant difference between the adhesion scores of honey vs artificial honey and control groups. The scores of histological changes of ileum in honey group were significantly different from other groups. These results indicate a protective role of honey against intraabdominal adhesions and anastomotic dehiscence.
    Phytotherapy Research 09/2008; 22(9):1243-7. DOI:10.1002/ptr.2457 · 2.40 Impact Factor