María A Regueira

Publications (2)7.85 Total impact

• Article: Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26.

  Maria A Regueira, Shaonly Samanta, Peter J Malloy, Paloma Ordonez-Moran, Diana Resende, Fredy Sussman, Alberto Munoz, Antonio Mourino, David Feldman, Mercedes Torneiro
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  ABSTRACT: We designed by docking and synthesized two novel analogues of 1α,25-dihydroxyvitamin D(3) hydroxymethylated at C-26 (2 and 3). The syntheses were carried out by the convergent Wittig-Horner approach via epoxide 12a as a common key intermediate. The antiproliferative and transactivation potency of the compounds was evaluated in colon and breast cancer cell lines. The analogues showed a similar but reduced activity compared to 1,25(OH)(2)D(3). Analogue 3 was more potent than analogue 2, and in some assays it exhibited potency similar to that of the natural ligand.
  Journal of Medicinal Chemistry 06/2011; 54(11):3950-62. · 4.80 Impact Factor
• Source

  Available from: Miguel Maestro

  Article: Synthesis of two carboxylic haptens for raising antibodies to 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3.

  Carlos Gregorio, Silvina Eduardo, Luis C Rodrigues, María A Regueira, Ramón Fraga, Ricardo Riveiros, Miguel Maestro, Antonio Mouriño
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  ABSTRACT: Hapten derivatives of 25-hydroxyvitamin D(3) and 1alpha,25-dihydroxyvitamin D(3) were synthesized using the Wittig-Horner approach. Both haptens bearing a carboxylic group at the side chain that can be linked to a protein for raising antibodies of potential utility for the determination of 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3) and 1alpha-hydroxylated vitamin D(3) analogues.
  The Journal of Steroid Biochemistry and Molecular Biology 04/2007; 103(3-5):227-30. · 3.05 Impact Factor