Maria Dobre

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Publications (2)0 Total impact

  • Article: [TGF-beta2 involvements in open angle glaucoma].
    C Stefan, L Dragomir, Diana Melinte Dumitrică, C Ursaciuc, Maria Dobre, Mihaela Surcel
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    ABSTRACT: To emphasize the correlation between TGF beta2 and primary open angle glaucoma (POAG). Observational clinical study on two groups of patients: group I--17 patients with POAG who need surgical approach and group II--16 patients without glaucoma. The groups were homogeneous regarding age and sex. The exclusion criteria were any associated systemic pathology. The concentration of TGF beta2 in the aqueous humor of each patient of both groups was measured by ELISA method. After the comparative analysis we observed that TGF beta2 was more increased in patients with POAG than in patients without the disease. The changes of trabecular extra cellular matrix are induced by many factors. TGF beta2 is a special cytokine witch is believed to increase the fibronectin concentration in the trabecular meshwork and alter the extra cellular matrix turn-over with a final profibrotic effect.
    Oftalmologia (Bucharest, Romania: 1990) 02/2008; 52(3):110-2.
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    Article: Regulatory T cells and TH1/TH2 cytokines as immunodiagnosis keys in systemic autoimmune diseases.
    Cornel Ursaciuc, Mihaela Surcel, Dan Ciotaru, Maria Dobre, Ioana Ruxandra Pirvu, Adriana Narcisa Munteanu, Mihail Alecu, Radu Huică
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    ABSTRACT: We assessed Helper T-cell involvement and possibilities to quantify the cell-based immune response in systemic autoimmune diseases (SAID) in 14 systemic lupus erythematosus (SLE) and 7 rheumatoid arthritis (RA) patients. The goals of investigation were T-CD4+/T-CD8+ ratio, regulatory T cells (Treg) status and TH1/TH2 serum cytokine profiles (IFN-gamma and IL-2, respectively IL-4 and IL-6). SLE group proved significant decreased average Treg value as compared to RA group and controls and showed significant low Treg incidence (86% patients). The distribution of high T-CD4+/T-CD8+ ratio registered no significant distinction among LES and RA groups. SAID patients presented low serum IFN-gamma (86% RA, 60% SLE), high IL-2 (57% RA) and high IL-6 (53% LES), but no significant IL-4 modification. We conclude that Treg percentage remains the only cellular criterion for SAID immune evaluation. In the same time, different secretion mechanisms seem to be involved in SAID, i.e. TH2 in SLE and TH1 in RA.
    Roumanian archives of microbiology and immunology 69(2):79-84.
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