Magdalena Torbus

Publications of Magdalena Torbus

• [Dementia--distribution and diagnostic criteria].

  Authors: Magdalena Torbus, Marek Ksol, Bogdan Mazur

  Wiadomości lekarskie (Warsaw, Poland : 1960). 01/2011; 64(1):43-8.

  The ageing of the population makes the health problems of elderly people a major issue in the work of various specialists. More and more people show cognitive functions disorders from minor toThe ageing of the population makes the health problems of elderly people a major issue in the work of various specialists. More and more people show cognitive functions disorders from minor to considerable ones. The most common cause of dementia is Alzheimer's disease. The diagnostic criteria of dementia in the course of Alzheimer's disease or the criteria of vascular dementia are described in this article. Although we mention the scales focused on cognitive functions disorders.

• Decreased numbers of CD4+ T lymphocytes in peripheral blood after treatment of childhood acute lymphoblastic leukemia.

  Authors: Bogdan Mazur, Tomasz Szczepański, Jacek Karpe, Danuta Sońta-Jakimczyk, Halina Bubała, Magdalena Torbus

  Leukemia research. 02/2006; 30(1):33-6.

  Treatment-related immunosuppression in patients with acute lymphoblastic leukemia (ALL) is associated with increased susceptibility to infectious diseases, also after the treatment. The aim of theTreatment-related immunosuppression in patients with acute lymphoblastic leukemia (ALL) is associated with increased susceptibility to infectious diseases, also after the treatment. The aim of the present study was the detailed evaluation of T lymphocyte subsets in peripheral blood in children after treatment of ALL. All children were treated according to the BFM 90 protocol. The patients were divided into 5 groups of 30 children in each, depending on the time from cessation of the ALL treatment. A control group consisted of 30 healthy children subjected to elective "1-day" surgery. The children's age ranged from 6 to 18 years. The examinations were performed in FACScan flow cytometer with the use of wide set of monoclonal antibodies: CD3, CD4, CD8, TCRalphabeta, TCRgammadelta, CD19, CD25, CD45RA, CD45RO, CD69, HLA-DR, CD16 and CD56, which particularly allowed detailed analysis of T lymphocytes. The results showed that most parameters in children 1 year after ALL treatment completion were similar to healthy children. However, we observed persistently low CD4+ T cell numbers, both CD45RA+ as well as CD45RO+ subsets as compared to the control group. This might reflect decreased regenerative potential of immunological system in children 1 year after ALL treatment.