[Show abstract][Hide abstract] ABSTRACT: Congenital cytomegaly is caused by intrauterine mother-to-fetus HCMV transmission and constitutes the most common vertical infection.
The aim of the study was to analyze the viremia level in maternal blood and its influence on the course and duration of pregnancy as well as newborn condition.
The material included blood samples collected from 117 pregnant women with serological features of HCMV infection and from 29 neonates hospitalized at DFMMG in Lodz between 1999 and 2009. The presence of HCMV DNA in the maternal and fetal blood was tested using real-time PCR.
Prevalence of maternal viremia was observed to increase the risk of viremia in neonates, as compared to children born to mothers with no viremia. However; lack of HCMV DNA in maternal blood does not exclude fetal infection in utero. Newborn condition assessed by Apgar scores was significantly lower in the group of infants born to mothers with serological features of acute cytomegaly (p < 0.05).
The assessment of viremia level in maternal blood can be helpful in assessing the risk of intrauterine infection in the fetus as well as in predicting the neonatal outcome of newborn.
Ginekologia polska 12/2013; 84(12):1005-11. · 0.79 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Human cytomegalovirus is a common etiological agent of infections and is the most common cause of intrauterine infections. Due to the scale and importance of infections during pregnancy in this study we investigated the incidence of specific IgG and IgM antibodies directed against HCMV in population of Polish pregnant women.
The retrospective study included 1332 pregnant women who were hospitalized at the DFMMG in Lodz between 1999 and 2009. In this group, 117 women had serological features of acute cytomegalovirus infections (study group) and 51 women were seronegative for IgG, IgM and IgA antibodies (control group). HCMV infections in pregnant women were diagnosed by serological assays (IgG, IgM, IgA, IgG avidity) and clinical symptoms.
Seroprevalence of CMV IgG was estimated to be 76.7% (n=985). Anti-HCMV immunoglobulin M antibodies were detected in 13% of pregnant women (n=179).
There was no significant correlation between the prevalence of IgG and IgM antibodies and factors such as maternal age, parity a number of births, place of residence and marital status.
Ginekologia polska 05/2012; 83(5):337-41. · 0.79 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Human cytomegalovirus (HCMV) is the most common congenital infection. HCMV strains display genetic variability in different regions. Distribution of HCMV genotypes in the population of congenitally infected newborns from Central Poland and viral load in newborns' blood is described and discussed. HCMV isolates were analysed by sequencing at three sites on the genome: the UL144 tumour necrosis factor-alpha (TNFα)-like receptor gene, the US28 beta-chemokine receptor gene and the UL55 envelope glycoprotein B (gB) gene. The newborns' blood was examined for HCMV DNA with a nested (UL144, UL55) or heminested (US28) polymerase chain reaction, and the genotypes were determined by sequence analysis. HCMV DNA was detectable in 25 out of 55 examined newborns born by HCMV-infected mothers (45.5%). The blood viral load in mother-infant pairs was determined. Most of the newborns had identical virus genotype, gB2 (96%), UL144 B1 (88%) and US28 A2 (84%). These genotypes were detected in all newborns with asymptomatic congenital infection. The occurrence of UL144 B1 or US28 A2 genotypes in the babies examined was significant in comparison to other genotypes (p=0.0002 and p=0.040 respectively). There was no association between specific gB subtypes in all patients groups (p=0.463). There was no correlation between HCMV genotypes and the outcome.
European Journal of Clinical Microbiology 11/2011; 31(7):1335-45. · 3.02 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The aim of our analysis was to retrospectively analyze the course of pregnancy and delivery in the group of Polish women, aged from 15 to 25.
We analyzed 345 woman, aged 15-25, treated in the KMMPiG ICZMP in Lodz between the years 2000 and 2006. The investigated patients were divided into two groups: 15-18-year-olds constituted the research group and 19-25-year-olds, that is the control group. Factors which have been taken into consideration included: pregnancy history, ultrasound examinations, delivery mode, birth weight and the APGAR score.
62.7% (n = 69) delivered naturally, 30.9% (n = 34) by caesarean section and 6.36% (n = 7) by forceps in the group of adolescents and 67.6% (n = 159), 32.4% (n = 71) and 2% (n = 5) (p = 0.379; OR 1.27) in the control group. 25.5% (n = 26) of the adolescent women (< 37 week of gestation, WG) and 20.7% (n = 48) of the controls (p = 0.39; OR 1.31) had a pre-term delivery. There were 3.9% multiparas in the group of teenagers and 20.7% among adolescents (p = 0.001). Fetal malformations were diagnosed prenatally in 13.7% (n = 14) of newborns delivered by adolescents mothers and 11.6% (n = 27) in the control group (p = 0.591; OR 1.21).
Despite the dangers connected with the young age of the mother, the results of this study allow us to state that teenage pregnancy usually has a correct course and does not differ significantly from the pregnancy of an adult woman.
Ginekologia polska 01/2009; 79(12):867-70. · 0.79 Impact Factor