Marc Seibolt

University of Tuebingen, Tübingen, Baden-Württemberg, Germany

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Publications (3)1.34 Total impact

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    ABSTRACT: To assess quality of life in patients with oropharyngeal carcinoma after primary surgery and postoperative irradiation. Retrospective chart review and patient response to the Short Form 36 (SF-36) Health Survey and the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-H&N35 questionnaires. A tertiary care university hospital. One hundred sixty-nine patients with oropharyngeal carcinoma underwent primary surgery followed by postoperative irradiation between January 1997 and February 2002. Eighty-eight disease-free survivors were identified in September 2002 and included in this study. The questionnaires were completed by 34 patients (39% completion rate). Median follow-up was 2.3 years (range 0.5-4.9 years). In oropharyngeal carcinoma patients, five scales of the SF-36 showed significantly reduced scores in comparison with the normal German population: physical functioning, role functioning - physical, general health, social functioning, and role functioning - emotional. Posttreatment scores from the literature fell within the 95% confidence interval of our data except one out of fifteen scales of the EORTC QLQ-C30 questionnaire and six out of eighteen scales of the EORTC QLQ H&N35 questionnaire. The comparison of our data with data from the reviewed literature produced similar results. General quality of life was reduced in our oropharyngeal carcinoma patients. Primary surgery and postoperative irradiation demonstrated similar results in different studies.
    The Journal of otolaryngology 11/2006; 35(5):332-7. · 0.50 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate the impact of patient characteristics and surgical interventions on quality of life (QoL) after primary surgery and postoperative irradiation in patients with oropharyngeal carcinoma. Between January 1997 and February 2002, 169 patients with carcinoma of the oropharynx were treated with curative intent. In September 2002, a total of 88 disease-free survivors were identified and included in this study. A retrospective chart review was performed and patient responses to the SF-36 Health Survey, EORTC QLQ-C30 and EORTC QLQ-H&N35 questionnaires were evaluated. The questionnaires were completed by 34 patients (39% response rate). All patients were treated with primary surgery followed by postoperative irradiation. The median follow-up was 2.3 years (range 0.5-4.9 years). Using Bonferroni-Holm adjustment for alpha, gender was found to be an important factor in QoL. Females scored significantly worse than males in all three questionnaires. We could not identify other factors influencing QoL. The impact of gender on QoL must be considered as very significant.
    HNO 05/2006; 54(5):376-81. · 0.42 Impact Factor
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    ABSTRACT: ZielDas Ziel dieser Studie bestand in der Evaluation des Einflusses von Patientencharakteristika und chirurgischen Interventionen auf die Bewertung der Lebensqualitt bei Patienten mit Oropharynxkarzinom nach primrer Resektion und postoperativer Radiatio.Patienten und MethodenVon Januar 1997 bis Februar 2002 wurden 169 Patienten mit Oropharynxkarzinomen mit kurativer Intention behandelt. Im September 2002 wurden 88 nach Aktenlage tumorfreie Patienten identifiziert und in die Studie eingeschlossen. Eine retrospektive Datenanalyse wurde durchgefhrt sowie eine postalische Befragung mit den Lebensqualitts-Fragebgen SF-36 Health Survey, EORTC QLQ-C30 und EORTC QLQ-H&N35. Diese wurden von 34 Patienten ausgefllt zurckgesandt (Antwortrate 39%).ErgebnisseAlle Patienten wurden primr operiert und adjuvant bestrahlt. Der mediane Nachverfolgungszeitraum betrug 2,3Jahre (Spannweite 0,5–4,9Jahre). Mittels Bonferroni-Holm--Adjustierung wurde das Geschlecht als wichtiger Faktor fr die Lebensqualitts-Bewertung identifiziert, wobei Frauen in allen 3Messinstrumenten schlechtere Bewertungen als Mnner abgaben. Weitere Faktoren mit Einfluss auf die Lebensqualitt wurden nicht gefunden.FazitDer Einfluss des Geschlechts auf die Bewertung der Lebensqualitt muss als sehr wichtig angesehen werden.BackgroundThe purpose of this study was to evaluate the impact of patient characteristics and surgical interventions on quality of life (QoL) after primary surgery and postoperative irradiation in patients with oropharyngeal carcinoma.Patients and methodsBetween January 1997 and February 2002, 169 patients with carcinoma of the oropharynx were treated with curative intent. In September 2002, a total of 88 disease-free survivors were identified and included in this study. A retrospective chart review was performed and patient responses to the SF-36 Health Survey, EORTC QLQ-C30 and EORTC QLQ-H&N35 questionnaires were evaluated. The questionnaires were completed by 34 patients (39% response rate).ResultsAll patients were treated with primary surgery followed by postoperative irradiation. The median follow-up was 2.3 years (range 0.5–4.9 years). Using Bonferroni-Holm adjustment for , gender was found to be an important factor in QoL. Females scored significantly worse than males in all three questionnaires. We could not identify other factors influencing QoL.ConclusionThe impact of gender on QoL must be considered as very significant.
    HNO 01/2006; 54(5):376-381. · 0.42 Impact Factor

Publication Stats

19 Citations
1.34 Total Impact Points

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Institutions

  • 2006
    • University of Tuebingen
      • Department of Otolaryngology, Head and Neck Surgery
      Tübingen, Baden-Württemberg, Germany