M E Selman

Universidad Nacional Autónoma de México, Mexico City, The Federal District, Mexico

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Publications (1)0 Total impact

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    ABSTRACT: In anesthetized guinea-pigs previously sensitized to ovalbumin by intratracheal immunization, the intravenous administration of propranolol (3.1 mg/kg) produced an increase in the respiratory insufflation pressure induced by ovalbumin. Atropine (2 mg/kg), zolertine (1 mg/kg) and indomethacin (3.1 mg/kg) did not antagonize the propranolol-induced airway hyperreactivity. Indomethacin at higher dose (10 mg/kg) and BW755c (10 mg/kg) decreased the potentiation of the respiratory insufflation pressure to ovalbumin. Our results suggest that besides the beta-blockade, propranolol-induced bronchial hyperreactivity to ovalbumin in sensitized guinea-pigs could be mediated by leukotrienes.
    Pharmacological Research Communications 01/1988; 19(12):887-900.

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Institutions

  • 1988
    • Universidad Nacional Autónoma de México
      • Department of Pharmacology
      Mexico City, The Federal District, Mexico