[Show abstract][Hide abstract] ABSTRACT: BACKGROUND: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART). METHODS: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients. RESULTS: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to100 000 copies/ml), were significantly associated with immunological and virological responses to HAART. CONCLUSIONS: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
Transactions of the Royal Society of Tropical Medicine and Hygiene 06/2013; · 1.82 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the demonstration that the actual virus is present in several body fluids. In this study, we investigated the relationship between the detection of HCV RNA in body fluids (saliva, cervical smears, seminal fluid and peripheral blood mononuclear cells) from chronically HCV-infected patients and several viral and host factors.
This study comprised 16 HIV/ HCV coinfected and 21 HCV monoinfected patients with a median age of 38 and 45 years, respectively. HCV-RNA was detected in serum and fluids samples by reverse transcription-nested polymerase chain reaction. Genotypes were determined by using RFLP and direct nucleotide sequencing of the PCR products and plasma viral loads by using NASBA HCV-QT.
When compared on the basis of the results of the detection of HCV-RNA in fluids, patients did not differ significantly in relation to viral load, genotype, HCV/HIV coinfection, and epidemiological host factors.
Our data suggest that HCV can be detected in body fluids of chronically HCV-infected patients independent of these cofactors, including circulating HCV load and HCV/HIV coinfection. Studies on HCV dynamics are needed to gain insights into nonparenteral transmission of HCV.
[Show abstract][Hide abstract] ABSTRACT: This is the first study reporting the epidemiological and molecular characterization of HCV/HIV coinfection in the central region of Argentina.
Cross-sectional, epidemiological study (2003-2004). Statistics: multivariate logistic regression analysis.
The incidence of HCV/HIV coinfection was 12.3%. HCV genotype 1 was the most prevalent (73%). Intravenous drug use was the main independent risk factor for acquiring HCV infection. However, an alternative route (sexual) for viral transmission was suggested.
These results underscore the potential public health impact of HCV/HIV coinfection in our region.