Luca Modolo

University of Lausanne, Lausanne, Vaud, Switzerland

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Publications (3)2.91 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Standardized uptake values (SUV) are widely used in positron emission tomography (PET) to quantify [18F]2-fluoro-2-deoxy-d-glucose (18F-FDG) uptake, particularly in therapeutic follow-up. However, this index depends on many factors, be they methodological or biological, and its use is still a subject of debate. In this context, it is fundamental to establish a regular quality control to ensure quantitative indices constancy. In this perspective, a specific phantom with different size cylinder-shaped inserts was developed. The purpose of this study is to show the sensitivity and the interest of this phantom.
    Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique - MED NUCL. 01/2008; 32(11):589-595.
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    ABSTRACT: Combined positron emission tomography and computed tomography (PET/CT) scanners play a major role in medicine for in vivo imaging in an increasing number of diseases in oncology, cardiology, neurology, and psychiatry. With the advent of short-lived radioisotopes other than 18F and newer scanners, there is a need to optimize radioisotope activity and acquisition protocols, as well as to compare scanner performances on an objective basis. The Discovery-LS (D-LS) was among the first clinical PET/CT scanners to be developed and has been extensively characterized with older National Electrical Manufacturer Association (NEMA) NU 2-1994 standards. At the time of publication of the latest version of the standards (NU 2-2001) that have been adapted for whole-body imaging under clinical conditions, more recent models from the same manufacturer, i.e., Discovery-ST (D-ST) and Discovery-STE (D-STE), were commercially available. We report on the full characterization both in the two- and three-dimensional acquisition mode of the D-LS according to latest NEMA NU 2-2001 standards (spatial resolution, sensitivity, count rate performance, accuracy of count losses, and random coincidence correction and image quality), as well as a detailed comparison with the newer D-ST widely used and whose characteristics are already published.
    Medical Physics 08/2007; 34(7):2708-17. · 2.91 Impact Factor
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    ABSTRACT: The goal of work is the characterization of two PET/CT units that are based on different technologies, using the methodology proposed in the NEMA NU 2-2001 standard. The two systems were qualified in the 3D acquisition mode by means of the National Electric Manufacturers Association (NEMA) phantoms. The results obtained showed that the NEMA standard allows to highlight differences in terms of spatial resolution, sensitivity, scatter fraction and counting rate performances between the two systems ; differences that can be explained by the geometry of the units and the materials of the detectors used. Thus, the use of the standard makes it possible to benchmark PET units and establish reference values that can be used to follow the stability of the system over the time. The tests of image quality, obtained under conditions closer to the clinical applications, showed nevertheless that the two units give, in spite of different technologies, images with sufficient contrast, within short acquisition times, allowing the detection of small lesions. This test should be part of the constancy tests to enable the comparison of examinations performed on different units when the quantitative aspects are of importance.
    Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique - MED NUCL. 01/2007; 31(8):372-379.