A Prodi

Università degli Studi di Trieste, Trst, Friuli Venezia Giulia, Italy

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Publications (11)25.58 Total impact

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    ABSTRACT: Background. Sensitization to nickel, cobalt and chromium is frequent in patch test populations. The prevalence is affected by geographical and socio-cultural factors. Objectives. To investigate the temporal trend of nickel, cobalt and chromium contact sensitization between 1996 and 2010 in north-eastern Italy. Patients/methods. Nineteen thousand and eighty-eight patients (67.2% women and 32.8% men) with suspected allergic dermatitis underwent patch testing with the European baseline series. The associations between nickel, cobalt and chromium sensitization and patient age (in quintiles) and year of patch testing were investigated by means of multivariate logistic regression analysis. Results. The prevalence of nickel sensitization decreased significantly among younger women (≤26 years), from 38.3% (1996-1998) to 31.9% (2002-2004), 28.3% (2005-2007) and 29.0% (2008-2010), whereas an increase was observed in the 36-45-year and 46-58-year age groups. The overall prevalence of chromium sensitization dropped from 10.2% (1996-1998) to 4.6% (2008-2010) among women, and from 11.3% (1996-1998) to 5.9% (2008-2010) among men. The prevalence of cobalt sensitization increased among younger men (≤26 years), from 2.7% (1996-1998) to 7.3% (1999-2001), 9.6% (2002-2004), and 6.6% (2005-2007). Conclusions. Our study showed a decreasing trend of nickel sensitization (only among younger women) and of chromium sensitization in both sexes.
    Contact Dermatitis 07/2012; · 2.93 Impact Factor
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    ABSTRACT: Background. Cosensitization to nickel, cobalt and chromium occurs in the general population and in some occupational groups. Objectives. To estimate the isolated and concurrent occurrence of nickel, cobalt and chromium contact sensitization and their association with individual and occupational risk factors. Patients/methods. Twelve thousand four hundred and ninety-two patients were patch tested with the European baseline series between 1997 and 2004 in north-eastern Italy. The associations between patch test results and patient characteristics and occupations were investigated by means of multinomial logistic regression analysis. Results. Of the patients, 34.7% (4334 patients) had one or more positive patch test reactions to metals. As compared with those with negative reactions to all three metals, nickel sensitization was significantly higher in females than in males, not only as monosensitization, but also as cosensitization with cobalt, with chromium, or with both metals. Building and related trades workers showed positive reactions to chromium + nickel [odds ratio (OR) 1.99; 95% confidence interval (CI) 1.05-3.76) and chromium + cobalt (OR 2.61; 95% CI 1.46-4.67]. Cleaning workers showed a high prevalence of nickel, chromium, nickel + chromium and nickel + cobalt + chromium cosensitization (ORs 1.29, 1.66, 2.11, and 1.79, respectively). An excess risk for cosensitization to all three metals was found in textile and leather workers (OR 2.19; 95% CI 1.10-4.33), and in bartenders (OR 2.10; 95% CI 1.03-4.26). Conclusions. Some occupational groups are more likely to develop nickel, cobalt and chromium cosensitization.
    Contact Dermatitis 05/2012; · 2.93 Impact Factor
  • Dermatitis 05/2012; 23(3):132-3. · 0.93 Impact Factor
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    ABSTRACT: To examine the association between two job stress models-the job strain (JDC) and the effort-reward imbalance (ERI) model-and ambulatory blood pressure monitoring in call handler operators. Participants included 74 women (age, 34.9 ± 9.9 years) and 26 men (age 36.0 ± 10.8 years) who were monitored on 2 workdays for ambulatory blood pressure. Measures of both job stress models were related to blood pressure by the generalized estimating equations (GEE) method while adjusting for potential confounders (gender, age, cigarette smoking, alcohol consumption, educational level, marital status, time of day, and work schedule). Workshifts were associated with an increase of 3-4 and 14 mmHg in mean arterial pressure (MAP) compared with diurnal activities out of work and sleeping period, respectively (P < 0.001). Ambulatory blood pressure was also significantly related with work schedule preference: unpleasant work schedule was associated with an increase of 2 mmHg in MAP compared with pleasant work schedule (P = 0.013). In the ERI model, subjects scoring high in work stress have higher ambulatory blood pressure at work, at home, and during sleep. Work stress by time interaction was not longer significant when controlling for potential confounders: generalized estimating equations revealed that MAP was influenced by BMI (>25 vs. <25: 0.7 (0.2-1.1) mmHg), workshift preference (unpleasant vs. pleasant: 2 (0.4-3.6) mmHg), and time of day. Weak not significant relation was found between ABP and psychosocial factors evaluated by the JDC and ERI models. These results do not support work stress as a significant factor influencing ABP in a homogeneous group of call-handlers. Complementary information independently obtained from the two work stress models could provide more exhaustive explanations on the stress-related effects on blood pressure.
    International Archives of Occupational and Environmental Health 04/2011; 84(4):383-91. · 2.10 Impact Factor
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    ABSTRACT: Exposure to nickel, cobalt and chromate are important causes of occupational contact dermatitis. To estimate the prevalence of nickel, cobalt and chromate allergy in a population of consecutive patients and to investigate the possible association with individual and occupational risk factors. A total of 14 464 patients (67.6% women and 32.4% men) with suspected allergic dermatitis underwent patch tests. The associations between patch test results and occupations were studied by multivariate logistic regression analysis. About 24.6% of the patients reacted positively to nickel sulphate, 10.2% to cobalt chloride and 8.7% to potassium dichromate. Nickel sensitization was higher in women aged 26-35 years in comparison with the youngest group (15-25 years) and the older group (> 45 years). In women, the prevalence of positive reactions to nickel was positively associated with metal and mechanical work (OR 1.54; 95%, CI 1.16-2.05). Chromate sensitization was more prevalent in building trade workers for both women (OR 1.58; 95% CI 1.00-2.49) and men (OR 2.24; 95% CI 1.55-3.22). Cobalt sensitization was associated with textile and leather work in women (OR 1.52; 95% CI 1.09-2.12) and with cleaning work in men (OR 1.86; 95% CI 1.18-2.93). Our study showed interesting associations between some occupations and nickel, chromate and cobalt allergy.
    Contact Dermatitis 04/2010; 62(4):225-31. · 2.93 Impact Factor
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    ABSTRACT: The supramolecular systems [Ru(Pyr(n)bpy)(CN)(4)](2-) (n = 1, 2), where one and two pyrenyl units are linked via two-methylene bridges to the [Ru(bpy)(CN)(4)](2-) chromophore, have been synthesized. The photophysical properties of these systems, which contain a highly solvatochromic metal complex moiety, have been investigated in water, methanol, and acetonitrile. In all solvents, prompt and efficient singlet-singlet energy transfer takes places from the pyrene to the inorganic moiety. Energy transfer at the triplet level, on the other hand, is dramatically solvent dependent. In water, the metal-to-ligand charge transfer (MLCT) emission of the Ru-based chromophore is completely quenched, and rapid (200 ps for n = 1) irreversible triplet energy transfer to the pyrene units is detected in ultrafast spectroscopy. In acetonitrile, the MLCT emission is practically unaffected by the presence of the pyrenyl chromophore, implying the absence of any intercomponent triplet energy transfer. In methanol, triplet energy transfer leads to an equilibrium between the excited chromophores, with considerable elongation of the MLCT lifetime. The investigation of the [Ru(Pyr(n)bpy)(CN)(4)](2-) systems in methanol provided a very detailed and self-consistent picture: (i) The initially formed MLCT state relaxes toward equilibrium in 0.5-1.3 ns (n = 1, 2), as monitored both by ultrafast transient absorption and by time-correlated single photon counting. (ii) The two excited chromophores decay with a common lifetime of 260-450 ns (n = 1, 2), as determined from the decay of MLCT emission (slow component) and of the pyrene triplet absorption. (iii) These equilibrium lifetimes are fully consistent with the excited-state partition of 12-6% MLCT (n = 1-2), independently measured from preexponential factors of the emission decay. Altogether, the results demonstrate how site-specific solvent effects can be used to control the direction of intercomponent energy flow in bichromophoric systems.
    Inorganic Chemistry 10/2003; 42(18):5489-97. · 4.59 Impact Factor
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    ABSTRACT: Eight adducts between different pyridylporphyrins and ruthenium complexes, MPyP[RuCl(2)(DMSO)(2)(CO)], c-DPyP[RuCl(2)(DMSO)(2)(CO)](2), TrPyP[RuCl(2)(DMSO)(2)(CO)](3), TPyP[RuCl(2)(DMSO)(2)(CO)](4), (MPyP)(2)[RuCl(2)(DMSO)(2)], [c-DPyP[RuCl(2)(DMSO)(2)]](2), MPyP[RuCl(2)(CO)(3)], and [c-DPyP[RuCl(2)(CO)(2)]](2), have been investigated. The results show that in all the adducts the porphyrin singlet is quenched, to a greater or lesser extent, relative to the parent-free molecule. This study provides insight into the mechanisms of singlet quenching in the adducts. Two mechanisms for singlet quenching, both related to the "heavy-atom effect" of the ruthenium center and experimentally distinguishable by transient spectroscopy, are examined. Enhanced intersystem crossing within the porphyrin chromophore is demonstrated for the series of adducts MPyP[RuCl(2)(DMSO)(2)(CO)], c-DPyP[RuCl(2)(DMSO)(2)(CO)](2), TrPyP[RuCl(2)(DMSO)(2)(CO)](3), and TPyP[RuCl(2)(DMSO)(2)(CO)](4), where a nice correlation is observed between the magnitude of the effect and the number of ruthenium centers attached to the pyridylporphyrin chromophore. Singlet-triplet energy transfer from the pyridylporphyrin chromophore to the ruthenium center(s) is an additional efficient quenching channel for adducts containing ruthenium centers with weak field ligands and low triplet energies, such as (MPyP)(2)[RuCl(2)(DMSO)(2)] and [c-DPyP[RuCl(2)(DMSO)(2)]](2).
    Inorganic Chemistry 08/2001; 40(14):3498-504. · 4.59 Impact Factor
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    ABSTRACT: {{The pentameric array of canted porphyrins (3'TPyP)[Ru(TPP)(CO)](4) (1) (3'TPyP = 5,10,15,20-tetra(3'-pyridyl)porphyrin
    Inorganic Chemistry 01/1999; 38(10):2527+. · 4.59 Impact Factor
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    ABSTRACT: Scavenging of SO2 and NH3 during ice growth by deposition of water vapour by diffusion was studied in a diffusion chamber at T=−6°C and −15°C. At both temperatures, we observed within the ice an increase of sulphur compounds, expressed as S(VI), for SO2 gas concentrations up to about 3 ppmv. At higher concentrations, saturation was reached in the ice phase. Addition of O3 to the flowing air produced an increase of S(VI) within the ice, at lower SO2 concentrations only. In experiments with NH3, we obtained at T=−15°C nitrogen compound concentrations, expressed as NH4+, regardless of the NH3 concentration in the gas phase in the range of concentrations tested, while at T=−6°C, NH4+ increased with increasing NH3. Concentrations of NH4+ and SO42− turned out to be higher at T=−6°C, compared to −15°C. By considering mixed runs at T=−15°C and −6°C, we observed an increase in both NH4+ and SO42− in the ice phase, compared to experiments at the same temperature, but with separate gases.
    Atmospheric Research - ATMOS RES. 01/1998; 47:209-217.
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    ABSTRACT: Scavenging of SO2 and NH3 during ice growth by deposition of water vapour by diffusion was studied in a diffusion chamber at T=−6°C and −15°C. At both temperatures, we observed within the ice an increase of sulphur compounds, expressed as S(VI), for SO2 gas concentrations up to about 3 ppmv. At higher concentrations, saturation was reached in the ice phase. Addition of O3 to the flowing air produced an increase of S(VI) within the ice, at lower SO2 concentrations only. In experiments with NH3, we obtained at T=−15°C nitrogen compound concentrations, expressed as NH4+, regardless of the NH3 concentration in the gas phase in the range of concentrations tested, while at T=−6°C, NH4+ increased with increasing NH3. Concentrations of NH4+ and SO42− turned out to be higher at T=−6°C, compared to −15°C. By considering mixed runs at T=−15°C and −6°C, we observed an increase in both NH4+ and SO42− in the ice phase, compared to experiments at the same temperature, but with separate gases.
    Atmospheric Research.
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    ABSTRACT: Nine hundred building trade workers and 4372 office workers (from a database of 16267 patients) with suspected allergic dermatitis, underwent patch tests. The associations between patch test results and occupations were assessed by multivariate logistic regression analysis. As expected, building trade work was significantly associated with chromium sensitization (OR 1.55; 95% IC 1.22-1.97), a well known occupational hapten in this occupational group. An increased risk for epoxy resin sensitization (OR 3.80; 95% IC 2.11-6.86) and thiuram mix sensitization (OR 1.69; 95% IC 1.07-2.65) was also found in the construction workers. Epoxy resin is a strong skin sensitizer widely used in building trade, while thiuram mix is often present as an additive in the rubber gloves used by construction workers. These findings suggest that effective measures to prevent allergic contact dermatitis are needed in the construction workers.
    Giornale italiano di medicina del lavoro ed ergonomia 34(3 Suppl):153-5.

Publication Stats

54 Citations
25.58 Total Impact Points

Institutions

  • 2001–2012
    • Università degli Studi di Trieste
      • • Clinical Unit of Occupational Medicine
      • • Department of Life Sciences
      • • Department of Chemical and Pharmaceutical Sciences
      Trst, Friuli Venezia Giulia, Italy
  • 2011
    • Università degli Studi di Torino
      Torino, Piedmont, Italy