[Show abstract][Hide abstract] ABSTRACT: Antisickling activity of anthocyanins extract from a Congolese plant ( Hymenocardia acida Tul.) was evaluated using Emmel test. Chromatographic separations using chloroform-benzene (2:1) provided three fractions A<sub>1</sub>, A<sub>2</sub> and A<sub>3</sub> with the most polar [A<sub>1</sub> (TLC, R<sub>f</sub> = 0.21)] exhibiting the highest activity. Thermal kinetic degradation of this fraction at 100 and 120°C produced a first order rate constants k = 2.64x10<sup>-4</sup> and 4.08x10<sup>-4</sup>, respectively. Structural elucidation of isolated compounds is in progress.