The objective of the study was to investigate the dynamics of changes in number of granulocytes in bacterial infections of carp (Cyprinus carpio). Carp were inoculated with non-pathogenic or pathogenic bacteria and changes in type I (neutrophils) and type II granulocyte (basophils/eosinophils) counts in kidney, circulating blood and peritoneal cavity were assessed. After the injection of non-pathogenic bacteria (Escherichia coli), the number of type I and II cells in blood increased after 6-12h, but returned to the control level after 24-48 h. In contrast, after the injection of pathogenic bacteria (Aeromonas hydrophila), the number of type I cells initially increased followed by an increase in the number of type II cells. The peak counts of type I and II cells were at 12 and 24h after the injection, respectively. When the fish were given serial-injections of formalin-killed bacteria at 12-h intervals, the type II cells also predominantly increased and remained at high levels, following the peak count of type I cells.
Veterinary Immunology and Immunopathology 12/2002; 90(1-2):101-5. DOI:10.1016/S0165-2427(02)00230-1 · 1.75 Impact Factor