K V Golovin

Are you K V Golovin?

Claim your profile

Publications (2)0.64 Total impact

  • Article: New Photosensitizers of Bacteriochlorin Series for Photodynamic Cancer Therapy
    A. F. Mironov, M. A. Grin, A. G. Tsiprovskii, A. V. Segenevich, D. V. Dzardanov, K. V. Golovin, A. A. Tsygankov, Ya. K. Shim
    [show abstract] [hide abstract]
    ABSTRACT: New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into -hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
    Russian Journal of Bioorganic Chemistry 02/2003; 29(2):190-197. · 0.64 Impact Factor
  • Article: [New photosensitizers of bacteriochlorin series for photodynamic cancer therapy].
    A F Mironov, M A Grin, A G Tsiprovskiĭ, A V Segenevich, D V Dzardanov, K V Golovin, A A Tsygankov, Ya K Shim
    [show abstract] [hide abstract]
    ABSTRACT: New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15- dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
    Bioorganicheskaia khimiia 29(2):214-21.
Browse more researchers