K Assmus

University of Greifswald, Griefswald, Mecklenburg-Vorpommern, Germany

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Publications (2)8.56 Total impact

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    ABSTRACT: The B-cell chronic lymphocytic leukemia (CLL)/lymphoma 11B gene (BCL11B) encodes a Krüppel-like zinc-finger protein, which plays a crucial role in thymopoiesis and has been associated with hematopoietic malignancies. It was hypothesized that BCL11B may act as a tumor-suppressor gene, but its precise function has not yet been elucidated. Here, we demonstrate that the survival of human T-cell leukemia and lymphoma cell lines is critically dependent on Bcl11b. Suppression of Bcl11b by RNA interference selectively induced apoptosis in transformed T cells whereas normal mature T cells remained unaffected. The apoptosis was effected by simultaneous activation of death receptor-mediated and intrinsic apoptotic pathways, most likely as a result of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) upregulation and suppression of the Bcl-xL antiapoptotic protein. Our data indicate an antiapoptotic function of Bcl11b. The resistance of normal mature T lymphocytes to Bcl11b suppression-induced apoptosis and restricted expression pattern make it an attractive therapeutic target in T-cell malignancies.
    Oncogene 06/2007; 26(26):3797-810. DOI:10.1038/sj.onc.1210152 · 8.56 Impact Factor
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    K Assmus · V Keuter · R Emmerich
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    ABSTRACT: This article presents results from dust measurement programmes in foundries of Tống Xá, Việt Nam and their interpretation and classification to Integrated water resource management (IWRM).

Publication Stats

34 Citations
8.56 Total Impact Points

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Institutions

  • 2007
    • University of Greifswald
      • Center for Internal Medicine
      Griefswald, Mecklenburg-Vorpommern, Germany