Juliana de Paoli

Publications (2)3.25 Total impact

• Article: IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury.

  André Luiz Dalla Libera, Andrea Regner, Juliana de Paoli, Leonara Centenaro, Tatiane Tolazzi Martins, Daniel Simon
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  ABSTRACT: The aim of this study was to test whether a functional polymorphism (-174C/G) located in the promoter region of the interleukin-6 (IL-6) gene is associated with primary short-term outcome (death or Intensive Care Unit discharge) in patients with severe traumatic brain injury (TBI). The study group consisted of 77 male patients who suffered severe TBI. The -174C/G IL-6 polymorphism was analysed by polymerase chain reaction (PCR) followed by restriction digestion. Severe TBI was associated with a 44% mortality rate. The GG genotype was significantly more frequent in the survivor group than in non-surviving patients (67% vs 41%; p =?0.038); similarly, the IL-6 -174G allele was more frequent in the survivor group than in non-surviving patients (81% vs 65%; p =0.031). The findings indicate that genetic variation regarding inflammatory response has significant impact on the short-term outcome for patients after acute severe TBI.
  Brain Injury 02/2011; 25(4):365-9. · 1.36 Impact Factor
• Article: Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.

  Sabrina Scherer, Thais Barboza de Souza, Juliana de Paoli, Claiton Viegas Brenol, Ricardo Machado Xavier, João Carlos Tavares Brenol, José Artur Chies, Daniel Simon
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  ABSTRACT: Several genetic factors seem to be involved in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to analyze whether functional polymorphisms in the promoter region of the MMP-1, -3 and -9 genes were associated with RA. The study population comprises 110 RA patients and 100 healthy controls. The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, and -1562 C/T MMP-9 polymorphisms were analyzed. The frequency of the 5A allele of MMP-3 gene was significantly higher in the controls when compared with the RA patients (0.45 vs. 0.32, P < 0.01). No significant differences were observed in the allele frequencies for the MMP-1 and -9 polymorphisms between RA patients and controls. Individuals carrying MMP-3 5A allele have significant higher frequency of extra-articular manifestations and rheumatoid nodules than individuals homozygous for 6A allele (P < 0.05). The results presented in this study provide evidence of an association between the MMP-3 gene polymorphism and RA.
  Rheumatology International 06/2009; 30(3):369-73. · 1.88 Impact Factor