Jitendra Sainy

Publications (2)2.18 Total impact

• Article: Synthesis and biological evaluation of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives as antidepressant, anxiolytics and anticonvulsant agents

  Rajesh Sharma, Ganesh Prasad Misra, Jitendra Sainy, Subhash Chandra Chaturvedi
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  ABSTRACT: A new series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for central nervous system activity. Compounds 1, 5, 7, 10, 14 exhibited significant antidepressant, anxiolytic and anticonvulsant activity in comparison to the reference drugs. Keywords2-Amino-5-sulfanyl-1,3,4-thiadiazole–Antidepressant–Anxiolytic and anticonvulsant activity
  Medicinal Chemistry Research 04/2012; 20(2):245-253. · 1.27 Impact Factor
• Source

  Available from: srce.hr

  Article: 2-Amino-5-sulfanyl-1,3,4-thiadiazoles: a new series of selective cyclooxygenase-2 inhibitors.

  Rajesh Sharma, Jitendra Sainy, Subhash Chandra Chaturvedi
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  ABSTRACT: A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.
  Acta Pharmaceutica 58(3):317-26. · 0.91 Impact Factor