Publications (2)2.87 Total impact
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Article: Interferon-alpha-induced deficits in novel object recognition are rescued by chronic exercise.
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ABSTRACT: The anti-viral drug interferon-alpha (IFN-alpha) is widely-known to induce psychiatric and cognitive effects in patients. Previous work has shown that physical exercise can have a positive effect against brain insult. We investigated the effects of a clinically-comparable treatment regime of IFN-alpha on cognitive function in male Wistar rats and assessed the impact of chronic treadmill running on the deficits generated by IFN-alpha. We found that IFN-alpha induced significant impairments in performance on both spatial novelty and object novelty recognition. Chronic forced exercise did not protect against IFN-alpha-induced learning deficits in reactivity to spatial change, but did restore the capacity for novel object recognition in IFN-alpha-treated animals.Physiology & Behavior 06/2008; 95(1-2):125-9. · 2.87 Impact Factor -
Article: Interferon-α-induced deficits in novel object recognition are rescued by chronic exercise
[show abstract] [hide abstract]
ABSTRACT: The anti-viral drug interferon-alpha (IFN-α) is widely-known to induce psychiatric and cognitive effects in patients. Previous work has shown that physical exercise can have a positive effect against brain insult. We investigated the effects of a clinically-comparable treatment regime of IFN-α on cognitive function in male Wistar rats and assessed the impact of chronic treadmill running on the deficits generated by IFN-α. We found that IFN-α induced significant impairments in performance on both spatial novelty and object novelty recognition. Chronic forced exercise did not protect against IFN-α-induced learning deficits in reactivity to spatial change, but did restore the capacity for novel object recognition in IFN-α-treated animals.Physiology & Behavior.
