Publications (2)1.83 Total impact
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Article: Alterations of motor nerve functions in animals exposed to motorcycle exhaust.
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ABSTRACT: The effect of motorcycle exhaust (ME) on the motor nerve was studied using animals exposed to the exhaust by inhalation, intratracheal, or intraperitoneal administration of ME particulate (MEP). A 4-wk ME inhalation and intratracheal instillation of MEP for 1 d in rats or intraperitoneal administration of MEP (0.5 g/kg/d for 1 d and 0.1 g/kg/d for 2 d) in mice significantly decreased both rota-rod performance and motor nerve conduction velocity. The effect of some polycyclic aromatic hydrocarbons on the motor nerve was also investigated. Treatment with benzo[a]pyrene (0.05 and 0.1 g/kg/d for 3 d), but not pyrene (0.1 g/kg/d for 3 d), resulted in significant decrease of motor nerve conduction velocity in mice. Moreover, the Na(+),K(+)-ATPase activities of sciatic nerves isolated from ME-, MEP-, or benzo[a]pyrene-exposed animals were decreased. Treatment with pyrene did not markedly affect the Na(+),K(+)-ATPase activity of sciatic nerve. The rats exposed to ME for 4 wk showed increases in blood and sciatic nerve manganese levels. Results indicate that motorcycle exhaust produces adverse effects on the motor nerve, which is associated with a fall in nerve Na(+),K(+)-ATPase activity.Journal of Toxicology and Environmental Health Part A 07/2002; 65(11):803-12. · 1.83 Impact Factor -
Article: Alterations in the Properties and Isoforms of Sciatic Nerve Na+,K+-ATPase in Methylcyclopentadienyl Manganese Tricarbonyl-Treated Mice
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ABSTRACT: The in vivo effect of methylcyclopentadienyl manganese tricarbonyl (MMT), an organic manganese-containing compound, on the mouse motor nerve was studied. The motor nerve conduction velocity was markedly decreased in MMT-treated mice. The Na+,K+-ATPase activity of sciatic nerve isolated from MMT-treated mice was decreased; however, the sciatic nerve Na+,K+-ATPase activity was not affected by the in vitro treatment of MMT. Moreover, [3H]ouabain binding of sciatic nerve isolated from MMT-treated mice was decreased. Using Western blot analysis, the amount of Na+,K+-ATPase catalytic α1 subunit polypeptide in sciatic nerve of MMT-treated mice was also decreased. These results indicate that a causal relationship may exist between reduced nerve Na+,K+-ATPase activity and motor nerve conduction velocity in MMT-treated mice and that a measurable decrease in α1 catalytic subunit isoform of Na+,K+-ATPase may be necessary for the development of peripheral neuropathy by MMT.Environmental Research. 82(3):239-244.
