James Cuvillier

Baylor College of Medicine, Houston, TX, United States

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Publications (1)33.61 Total impact

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    ABSTRACT: Liver mass depends on one or more unidentified humoral signals that drive regeneration when liver functional capacity is diminished. Bile acids are important liver products, and their levels are tightly regulated. Here, we identify a role for nuclear receptor–dependent bile acid signaling in normal liver regeneration. Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR. We propose that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver. FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth.
    Science 05/2006; 312(5771):233-6. DOI:10.1126/science.1121435 · 33.61 Impact Factor

Publication Stats

315 Citations
33.61 Total Impact Points

Top Journals


  • 2006
    • Baylor College of Medicine
      • Department of Molecular & Cellular Biology
      Houston, TX, United States