I P Grunyushkin

Publications (1)1.06 Total impact

• Article: Role of acetylcholine in regulation of interaction between axon and Schwann cell during rhythmic excitation of nerve fibers.

  G V Maximov, V V Revin, I P Grunyushkin, O R Kols
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  ABSTRACT: Axon excitation increases the number of acetylcholine receptors (ACR) of the Schwann cell (SC) depending on the frequency of rhythmic excitation (RE) and on intercellular concentrations of K+, Ca2+, and acetylcholine. During RE, activity of axonal acetylcholine esterase is decreased, thus providing for high intercellular acetylcholine concentration. Increased intercellular concentration of acetylcholine activates phosphoinositide-specific phospholipase C (PIPLC) of the myelin nerve fiber. During RE, K+ depolarization and acetylcholine exocytosis can activate Ca2+ entry via Ca2+ channels, thus inducing SC ACR phosphorylation mediated by PIPLC stimulation.
  Biochemistry (Moscow) 05/2000; 65(4):431-5. · 1.06 Impact Factor