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ABSTRACT: Objective. Healthcare-acquired infections (HAIs) cause substantial patient morbidity and mortality. Items in the environment harbor microorganisms that may contribute to HAIs. Reduction in surface bioburden may be an effective strategy to reduce HAIs. The inherent biocidal properties of copper surfaces offer a theoretical advantage to conventional cleaning, as the effect is continuous rather than episodic. We sought to determine whether placement of copper alloy-surfaced objects in an intensive care unit (ICU) reduced the risk of HAI. Design. Intention-to-treat randomized control trial between July 12, 2010, and June 14, 2011. Setting. The ICUs of 3 hospitals. Patients. Patients presenting for admission to the ICU. Methods. Patients were randomly placed in available rooms with or without copper alloy surfaces, and the rates of incident HAI and/or colonization with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) in each type of room were compared. Results. The rate of HAI and/or MRSA or VRE colonization in ICU rooms with copper alloy surfaces was significantly lower than that in standard ICU rooms (0.071 vs 0.123; [Formula: see text]). For HAI only, the rate was reduced from 0.081 to 0.034 ([Formula: see text]). Conclusions. Patients cared for in ICU rooms with copper alloy surfaces had a significantly lower rate of incident HAI and/or colonization with MRSA or VRE than did patients treated in standard rooms. Additional studies are needed to determine the clinical effect of copper alloy surfaces in additional patient populations and settings.
Infection Control and Hospital Epidemiology 05/2013; 34(5):479-86. · 3.67 Impact Factor
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Michael G Schmidt, Hubert H Attaway,
Peter A Sharpe,
Joseph John,
Kent A Sepkowitz,
Andrew Morgan,
Sarah E Fairey,
Susan Singh,
Lisa L Steed,
J Robert Cantey,
Katherine D Freeman,
Harold T Michels,
Cassandra D Salgado
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ABSTRACT: The contribution of environmental surface contamination with pathogenic organisms to the development of health care-associated infections (HAI) has not been well defined. The microbial burden (MB) associated with commonly touched surfaces in intensive care units (ICUs) was determined by sampling six objects in 16 rooms in ICUs in three hospitals over 43 months. At month 23, copper-alloy surfaces, with inherent antimicrobial properties, were installed onto six monitored objects in 8 of 16 rooms, and the effect that this application had on the intrinsic MB present on the six objects was assessed. Census continued in rooms with and without copper for an additional 21 months. In concert with routine infection control practices, the average MB found for the six objects assessed in the clinical environment during the preintervention phase was 28 times higher (6,985 CFU/100 cm(2); n = 3,977 objects sampled) than levels proposed as benign immediately after terminal cleaning (<250 CFU/100 cm(2)). During the intervention phase, the MB was found to be significantly lower for both the control and copper-surfaced objects. Copper was found to cause a significant (83%) reduction in the average MB found on the objects (465 CFU/100 cm(2); n = 2714 objects) compared to the controls (2,674 CFU/100 cm(2); n = 2,831 objects [P < 0.0001]). The introduction of copper surfaces to objects formerly covered with plastic, wood, stainless steel, and other materials found in the patient care environment significantly reduced the overall MB on a continuous basis, thereby providing a potentially safer environment for hospital patients, health care workers (HCWs), and visitors.
Journal of clinical microbiology 05/2012; 50(7):2217-23. · 4.16 Impact Factor
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ABSTRACT: BACKGROUND: Commonly touched items are likely reservoirs from which patients, health care workers, and visitors may encounter and transfer microbes. A quantitative assessment was conducted of the risk represented by the intrinsic bacterial burden associated with bed rails in a medical intensive care unit (MICU), and how disinfection might mitigate this risk. METHODS: Bacteria present on the rails from 36 patient beds in the MICU were sampled immediately before cleaning and at 0.5, 2.5, 4.5, and 6.5 hours after cleaning. Beds were sanitized with either a bottled disinfectant (BD; CaviCide) or an automated bulk-diluted disinfectant (ABDD; Virex II 256). RESULTS: The majority of bacteria recovered from the bed rails in the MICU were staphylococci, but not methicillin-resistant Staphylococcus aureus. Vancomycin-resistant enterococci were recovered from 3 beds. Bottled disinfectant reduced the average bacterial burden on the rails by 99%. However, the burden rebounded to 30% of that found before disinfection by 6.5 hours after disinfection. ABDD reduced the burden by an average of 45%, but levels rebounded within 2.5 hours. The effectiveness of both disinfectants was reflected in median reductions to burden of 98% for BD and 95% for ABDD. CONCLUSIONS: Cleaning with hospital-approved disinfectants reduced the intrinsic bacterial burden on bed rail surfaces by up to 99%, although the population, principally staphylococci, rebounded quickly to predisinfection levels.
American journal of infection control 02/2012; · 3.01 Impact Factor
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ABSTRACT: Effective cleaning of the patient environment has been advocated to reduce the risk for nosocomial infection. This pilot study compared 2 terminal cleaning methods, a traditional method in which a disinfectant was applied with a wetted cloth and an alternative method in which the disinfectant was applied using the PureMist system (PureCart Systems, Green Bay, WI). There was no difference in effectiveness, with a mean relative reduction of microbial burden of 84% for the traditional method versus 88% for the PureMist method.
American journal of infection control 10/2011; 40(6):559-61. · 3.01 Impact Factor
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ABSTRACT: A co-culture of two Pseudomonas putida isolates was enriched from sediment on a mixture of benzene, toluene, ethylbenzene, m-xylene, p-xylene, and o-xylene. The co-culture readily degraded each of the compounds present. Benzene, toluene, and ethylbenzene were used as growth substrates by one isolate, while toluene, m-xylene, and p-xylene were used as growth substrates by the other. Neither isolate could grow on o-xylene, but it was removed in the presence of the other compounds presumably by co-metabolism. The findings presented here support other reports in which constructed communities were effectively used to degrade blends of between two and four of the components of BTEX. However, here the co-culture of two P. putida isolates effectively degraded a complete BTEX stream containing all six of the components.
Current Microbiology 08/2002; 45(1):30-6. · 1.82 Impact Factor
