Hsiu-Kuan Wang

Publications (2)4.28 Total impact

• Article: Interleukin-1alpha and -1beta promoter polymorphisms in Taiwanese patients with dementia.

  Hsiu-Kuan Wang, Wen-Chuin Hsu, Hon-Chung Fung, Jun-Cheng Lin, Hai-Pei Hsu, Yih-Ru Wu, Yuying Hsu, Fen-Ju Hu, Guey-Jen Lee-Chen, Chiung-Mei Chen
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  ABSTRACT: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1alpha -889 C/T and IL-1beta -511 C/T promoter polymorphisms are associated with the risk of Alzheimer's disease (AD) and vascular dementia (VaD). AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1alpha -889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1alpha -889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12-0.83, p = 0.026). Multivariate analysis revealed that the IL-1beta -511T-carrying genotype slightly strengthens the negative association of the IL-1alpha -889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08-0.79, p = 0.024). Our data suggest a protective role of the IL-1alpha -889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.
  Dementia and Geriatric Cognitive Disorders 02/2007; 24(2):104-10. · 2.14 Impact Factor
• Article: Interleukin-1α and -1β Promoter Polymorphisms in Taiwanese Patients with Dementia

  Hsiu-Kuan Wang, Wen-Chuin Hsu, Hon-Chung Fung, Jun-Cheng Lin, Hai-Pei Hsu, Yih-Ru Wu, Yuying Hsu, Fen-Ju Hu, Guey-Jen Lee-Chen, Chiung-Mei Chen
  [show abstract] [hide abstract]
  ABSTRACT: Background: Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. We investigated whether IL-1α –889 C/T and IL-1β –511 C/T promoter polymorphisms are associated with the risk of Alzheimer’s disease (AD) and vascular dementia (VaD). Methods: AD patients (n = 219) and VaD patients (n = 82), who fulfilled the criteria of the NINCDS-ADRDA and NINDS-AIREN, and ethnic-matched and nondemented controls (n = 209) were analyzed by means of genotype association method. Results: No significant difference in the genotype distribution of the analyzed single nucleotide polymorphisms was found between AD or VaD cases and controls. However, the frequency of the IL-1α –889 CT genotype was notably lower in VaD patients aged over 70 years than the age-matched controls (9.1 vs. 22.9%, p = 0.036) andtheIL-1α –889 CT genotype demonstrated a trend toward decrease in risk of developing VaD (odds ratio: 0.34; 95% confidence interval: 0.12–0.83, p = 0.026). Multivariate analysis revealed that the IL-1β –511T-carrying genotype slightly strengthens the negative association of the IL-1α –889 CT genotype with VaD (odds ratio: 0.26; 95% confidence interval: 0.08–0.79, p = 0.024). Conclusion: Our data suggest a protective role of the IL-1α –889 CT genotype in VaD susceptibility among Taiwanese aged over 70 years.
  Dementia and Geriatric Cognitive Disorders 08/1970; 24(2):104-110. · 2.14 Impact Factor