Gui-Feng Wang,
Li-Ping Shi,
Yu-Dan Ren,
Qun-Fang Liu, Hou-Fu Liu,
Ru-Jun Zhang,
Zhuang Li,
Feng-Hua Zhu,
Pei-Lan He,
Wei Tang,
Pei-Zhen Tao,
Chuan Li,
Wei-Min Zhao,
Jian-Ping Zuo
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ABSTRACT: Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
Antiviral research 09/2009; 83(2):186-90. · 3.61 Impact Factor
