H Abessolo

Publications (2)2.15 Total impact

• Article: In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites.

  L Delhaes, H Abessolo, C Biot, L Berry, P Delcourt, L Maciejewski, J Brocard, D Camus, D Dive
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  ABSTRACT: Previous studies have shown that ferrochloroquine (FQ) exhibited an antimalarial activity against Plasmodium spp. The present work confirmed this activity, described the curative effect on P. vinckei and investigated the FQ toxicity in vitro and in vivo. The in vitro and in vivo growth inhibition of P. falciparum and P. berghei N, respectively, showed that FQ antimalarial activity was 1.5-10 times more potent than chloroquine. FQ completely inhibited the in vivo development of both chloroquine-susceptible and resistant P. vinckei strains and protected mice from lethal infection at a dose of 8.4 mg kg(-1) day(-1) given for 4 days subcutaneously or orally. This curative effect was 5-20 times more potent than chloroquine, according to the strains' resistance to chloroquine. At this curative dose, no clinical changes were observed in mice up to 14 days after the last administration. Nevertheless, the acute toxicity and lethality of ferrochloroquine seemed to be dependent on gastric surfeit. The FQ security index determined in vitro confirmed that it might be a promising compound.
  Parasitology Research 04/2001; 87(3):239-44. · 2.15 Impact Factor
• Article: Novel metallocenic compounds as antimalarial agents. Study of the position of ferrocene in chloroquine

  C Biot, L Delhaes, H Abessolo, O Domarle, L.A Maciejewski, M Mortuaire, P Delcourt, P Deloron, D Camus, D Dive, J.S Brocard
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  ABSTRACT: The synthesis, characterization and antimalarial activity of two new ferrocene–chloroquine compounds are reported. One of them, 7-chloro-4-N-[(4-N′-ethyl-N′-ferrocenylmethyl)ammonio-1-methylbutylamino]quinolin-1-ium bi-tartrate (2) showed very promising antimalarial activity in vivo on mice infected with Plasmodium berghei N. and Plasmodium yoelii NS. and in vitro against chloroquine resistant-strains of Plasmodium falciparum.
  Journal of Organometallic Chemistry.