Guadalupi Valentina

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Publications (2)0 Total impact

  • Article: Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron
    Bajetta Emilio, Pusceddu Sara, Guadalupi Valentina, al et
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    ABSTRACT: Emilio Bajetta, Sara Pusceddu, Valentina Guadalupi, Monika Ducceschi, Luigi CelioMedical Oncology Unit 2, Fondazione IRCCS “Istituto Nazionale dei Tumori”, Milan, ItalyAbstract: Prevention of nausea and vomiting is the main goal of antiemetic treatment in cancer patients scheduled to receive chemotherapy. To prevent acute emesis, antiemetics should be administered just before chemotherapy and patients should be protected for up to 24 hours after chemotherapy initiation. The emetogenic potential of chemotherapeutic agents guides clinicians towards the most appropriate antiemetic prophylaxis. Current guidelines recommend the use of 5-HT3 receptor antagonist (RA) either alone or in combination with dexamethasone and/or a neurokinin-1 RA both in the acute and delayed phases. The second-generation 5-HT3RA palonosetron exhibits a longer half-life and a higher binding affinity than older antagonists. Palonosetron has been approved by the FDA for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients scheduled to receive either moderately (MEC) or highly emetogenic chemotherapy (HEC) and for the prevention of delayed CINV in patients receiving MEC. The present review will discuss the role of palonosetron in the prevention of acute CINV.Keywords: antiemetics, chemotherapy, nausea, vomiting, serotonin-receptor antagonists, palonosetron
    Cancer Management and Research. 01/2009;
  • Article: Sorafenib in Hepatocellular Carcinoma
    Bajetta Emilio, Procopio Giuseppe, Colombo Andrea, Guadalupi Valentina, Verzoni Elena, Pietrantonio Filippo, Pusceddu Sara, Manzoni Mariangela, Gevorgyan Arpine, Buzzoni Roberto
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    ABSTRACT: Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with approximately 500,000 new cases per year, ranking as the third cause of cancer deaths. Until the very recent past no systemic therapy was available for patients with advanced HCC. However, advances achieved in the understanding of the molecular cancer biology and the subsequent introduction of molecularly targeted agents have disclosed promising and interesting possibilities for the treatment of this highly vascularized tumor in which the inhibition of angiogenesis is likely to represent the main potential therapeutic target. In this regard, sorafenib, an oral multikinase inhibitor endowed with significant activity against several tyrosine-kinase receptors involved in blood vessel development, has shown to be very active in the treatment of advanced HCC. This review makes a survey of pharmacology, mode of action, pharmacokinetics, clinical value and safety of sorafenib when employed in the treatment of advanced HCC.
    Clinical Medicine : Therapeutics. 01/2009;
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