George E. Eriyamremu

Publications (2)1.53 Total impact

• Article: Bioaccumulation of cadmium and its biochemical effect on selected tissues of the catfish (Clarias gariepinus).

  Samuel O Asagba, George E Eriyamremu, Mabel E Igberaese
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  ABSTRACT: The present study examines the pattern of accumulation of cadmium (Cd) and its biochemical effects on selected tissues of a variety of African catfish (Clarias gariepinus), after exposure to various doses of Cd. The results obtained indicate that at the end of 21 days of exposure, the total tissue organ cadmium concentration followed the pattern kidney > gill > liver > muscle for each of the exposure concentrations. The levels of Cd in these organs were higher than those in ambient water. Moreover, while the rate of uptake of Cd increased with time in the kidney, liver and muscle, it decreased in the gill. Superoxide dismutase (SOD) was significantly elevated only in the kidney of catfish treated with 0.2 and 0.4 ppm of Cd for 7 days compared with the control. Conversely, gill SOD was significantly decreased in the same concentrations of Cd-treated catfish relative to the control. Statistically similar levels of SOD were observed in the liver, brain and muscle with all the treatments after the same duration of treatment. In the fish exposed for 21 days, SOD activity was significantly decreased in the kidney with a corresponding increase in lipid peroxidation (LPO), but it manifested only with the 0.2- and 0.4-ppm Cd treatment relative to the control. In the liver, however, Cd exposure significantly increased SOD in the 0.2- and 0.4-ppm treatments of the same duration. In conclusion, the present study indicates that the accumulation of Cd and its effect on SOD and LPO in C. gariepinus is dependent on concentration, tissue and time.
  Fish Physiology and Biochemistry 03/2008; 34(1):61-9. · 1.53 Impact Factor
• Article: Effect of Lipid-Based Diet on Some Lipid-Metabolizing Enzymes

  E. Chukwu Onyeneke, Kayode E. Adebisi, George E. Eriyamremu, Samuel I. Ojeaburu, Samuel O. Asagba, Olaruwaju M. Oluba
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  ABSTRACT: The effects of long-term feeding of lipid-based diet (containing 5 and 10% cholesterol) on some lipid-metabolizing enzymes were examined by determining the activities of Lecithin: Cholesterol Acyl Transferase (LCAT), lipoprotein lipase (LPL) and triglyceride lipase (TGL). The LCAT activity was found to increase significantly (p< 0.05) in the cholesterol fed rats when compared to control animals fed the control diet and the increase was found to be dose dependent. The cholesterol fed rats also showed relatively significant (p< 0.05) increases in the levels of both cholesterol ester and free cholesterol. Similarly, both LPL and TG lipase activities were also significantly (p< 0.05) elevated in the cholesterol fed rats when compared to control. Histochemical evaluation of the liver of the rats fed 10% cholesterol at the end of the feeding period revealed chronic venous congestion and fatty changes. The kidney showed fat embolism with glomerular capillaries distended with fat globules. The aorta lumen was reduced to less than half the normal diameter by a greatly thickened intima which contained cholesterol crystals, typical of artheromatous plague. The implications of these findings are discussed with respect to artherogenesis, hyperlipoproteinemia and hypertriglyceridemia.
  Journal of Medical Sciences. 01/2007;