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Publications (2)0 Total impact

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    ABSTRACT: In clinical chemistry, a necessary step performed is the isolation of plasma from whole blood, and effective sample preparation techniques are needed for the development of miniaturized clinical diagnostic devices. This study demonstrates the use of passive microfluidic devices, which operating entirely on capillary action, for on-chip isolation of plasma from whole blood. Using these devices, several to several tens nanoliter volumes of plasma were effectively separated from a single drop of whole blood in 2 minutes. This study may have broad implications in the design of lab-on-a-chip devices for bioanalytical applications.
    Micro-NanoMechatronics and Human Science, 2007. MHS '07. International Symposium on; 12/2007
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    ABSTRACT: A microdevice for blood plasma separation using capillary phenomenon has been proposed in this work. Blood plasma can be separated by microcapillary channels fabricated by silicon bulk- micromachining process. The 2 times 3 cm<sup>2</sup> device with 1 mm-thick consists of a silicon separation chip and a glass cover. The separation was relatively fast (less than 2 minutes) after a blood-drop (20 mul) was drawn into the channels until the flow stopped. The device was designed for collecting 1 mul of plasma. Due to the advantages in a small sample volume, no power consumption, made the device possible for a blood diagnosis on a chip which promises the applications in point-of-care testing (POCT).
    Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International; 07/2007