F W G Hill

Publications (3)1.25 Total impact

• Article: Treatment of ocular squamous cell carcinomas in cattle with interleukin-2.

  R J E Stewart, F W G Hill, A Masztalerz, J J L Jacobs, J W Koten, W Den Otter
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  ABSTRACT: In total, 174 bovine ocular squamous cell carcinomas of varying sizes (20 to 2800 mm(2) in area) were treated daily with peritumoural injections of solvent, or solvent containing 5000 U, 20,000 U, 200,000 U, 500,000 U, 1 million U or 2 million U interleukin-2 (IL-2) for 10 days. The tumours were measured and clinically staged before treatment and at one, three, four, nine and 20 months after treatment. After 20 months, 14 per cent of the tumours treated with the solvent had regressed completely, a significantly smaller proportion than the 55 per cent treated with 5000 U IL-2, 52 per cent treated with 20,000 U IL-2, 58 per cent treated with 200,000 U IL-2, 50 per cent treated with 500,000 U IL-2, 69 per cent of tumours treated with 1 million U IL-2, 52 per cent treated with 2 million U IL-2. The tumours on the third eyelid and limbus were the most responsive.
  The Veterinary record 12/2006; 159(20):668-72. · 1.25 Impact Factor
• Article: Antitumor effect of locally injected low doses of recombinant human interleukin-2 in bovine vulval papilloma and carcinoma

  F.W.G. Hill, W.R. Klein, M.J. Hoyer, V.P.M.G. Rutten, N. Kock, J.W. Koten, P.A. Steerenberg, E.J. Ruitenberg, W. Den Otter
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  ABSTRACT: In many human clinical trials and in various animal tumor models, the antitumor effect of high doses of systemically applied interleukin-2 (IL-2) is tested. Our studies focused on the effects of low doses of locally injected IL-2. In this paper, the effect of local injection of low doses of IL-2, i.e. a total dose of 25 000–50 000 units, into papillomas or carcinomas of the bovine vulva is described. In 19 out of 23 (83%) cows treated with IL-2 an effect on the tumor load was observed; in three of these animals, complete regression was obtained. In the majority of cases, regression was not restricted to the tumors injected with IL-2.
  Veterinary Immunology and Immunopathology.
• Article: Concurrent systemic cryptococcosis and haemangiosarcoma in a dog

  Nancy D. Kock, E.P. Lane, F. Rowbotham, A. Pawandiwa, F.W.G. Hill
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  ABSTRACT: A young dog with progressive neurological signs was humanely killed by the injection of barbiturate for postmortem examination. Lesions in the nose, lung, pancreas, lymph nodes, kidneys and the meninges were heavily infiltrated with Cryptococcus neoformans. In addition, haemangiosarcoma was detected in the right atrium. The finding of systemic mycosis and neoplasia together in a young dog suggests an immunosuppressed state.
  Journal of Comparative Pathology. 104(1):117-120.