G P Mikhaĭlova

Publications (9)0 Total impact

• Article: [Microcirculation in the liver in normal blood oxygenation and hypoxemia].

  K P Ivanov, M K Kalinina, Iu I Levkovich, N A Mal'tsev, G P Mikhaĭlova
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  ABSTRACT: Vital contact microscopy and microfilming were used to measure the blood flow velocity in hepatic sinusoids 11 +/- 1 microns in diameter. The white blood cells moving in the axis stream of the red cells were used as the markers to measure linear flow velocity. In normoxia it was equal to 0.29 +/- 0.01 mm/sec and the volumetric flow rate in a liver sinusoid as calculated from this value was about 1.65 . 10(-3) microliters/min. Breathing with the mixture of nitrogen and 7% oxygen evoked a decrease of arterial blood pressure down to 80-70 torr and oxygen tension in a. femoralis and v. porta down to 45 +/- 3 torr and 18 +/- 3 torr, resp., as compared with 77 +/- 3 and 41 +/- 2 torr in normoxia. The mean sinusoidal blood flow velocity increased by nearly 12% only (p less than 0.01). This suggests that the increased oxygen extraction is the main compensatory mechanism in liver tissue hypoxia.
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 09/1982; 68(8):1165-70.
• Article: [Compensatory microcirculatory changes in the brain in oxygen deficiency].

  K P Ivanov, M K Kalinina, Iu I Levkovich, G P Mikhaĭlova
  Doklady Akademii nauk SSSR 02/1981; 261(2):506-9.
• Article: [Blood flow in skeletal muscle microvessels in normoxia and arterial hypoxemia (microcinematographic studies)].

  M K Kalinina, Iu I Levkovich, K P Ivanov, G P Mikhaĭlova
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  ABSTRACT: Vital microfilming revealed peculiarities of blood flow in microvessels of 2-5-micron diameter under relatively resting conditions, in normoxia, as well as the microcirculatory response to hypoxia (breathing with mixture of nitrogen and 6-8% oxygen for 5 min), in intact temporal muscle of rat. The average blood flow velocity in normoxia was 1.14 +/- 0.04 mm/sec in capillaries and 2.43 +/- 0.08 mm/sec in terminal arterioles. Breathing with the hypoxic mixture decelerated blood flow in 75% of the vessels. The blood low velocity in the muscle capillaries correlated with arterial blood pressure.
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 05/1979; 65(4):620-8.
• Article: [Neuro-hormonal mechanisms of hypothalamic influences on the tonus of cerebral vessels].

  S I Teplov, E A Borisova, G P Mikhaĭlova
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  ABSTRACT: In anesthetized cats, stimulation of supraoptic nuclei (SON) and dorso-lateral hypothalamus (DLH) led to cerebral vasoconstriction if not prevented by alpha-adrenoblocking drugs. The SON stimulation entailed activation of both the synthesis and the transport of neurosecretory substances and increased the neurohormone release into the blood flow. Delayed ("hormonal") vasoconstrictory responses occurred in these experiments. Stimulation of the preoptic area evoked moderate cerebral vasodilatation, later decreased or blocked by atropine. Neurohormone (vasopressin) seems to participate in the vasoconstriction evoked by the SON stimulation.
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 05/1978; 64(4):467-74.
• Article: [Adrenergic mechanisms of cerebrovascular neurogenic reactions].

  G P Mikhaĭlova
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 12/1974; 60(11):1677-83.
• Article: [Stereotaxic study of the spinal cord lateral horn in the cat].

  V P Lebedev, G P Mikhaĭlova
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 06/1971; 57(5):677-83.
• Article: [Use of thermography for studying the autoregulatory reactions of the cerebral vessels].

  D I Parolla, G P Mikhaĭlova
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 05/1970; 56(4):625-31.
• Article: [Mechanism of hyperemia induced by temporal interruption of cerebral vessel blood flow].

  A I Parolla, G P Mikhaĭlova
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 11/1968; 54(10):1186-92.
• Article: [Constrictor and dilator responses of the cerebral vessels in relation to their initial tone].

  D I Parolla, G P Mikhaĭlova
  Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova 05/1967; 53(4):400-8.