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ABSTRACT: We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor kappaB (NF-kappaB) and peroxisome proliferator-activated receptor gamma (PPARgamma) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-kappaB suppression and PPARgamma activation.
Annals of the New York Academy of Sciences 12/2002; 973:241-5. · 4.38 Impact Factor