[Show abstract][Hide abstract] ABSTRACT: At the neuromuscular junction, several endogenous substances have been shown to act presynaptically to modify transmitter release. Here we show that angiotensin 1-7, a vasoactive peptide of the renin-angiotensin system, increased quantal content in a dose-dependent manner, with a maximal increase of 78% at 250 nM. At the same dose, angiotensin 1-7 increased paired pulse facilitation by 70%. This is the first report of angiotensin 1-7 altering a cholinergic synapse.
Brain Research 03/2002; 927(2):208-11. DOI:10.1016/S0006-8993(01)03357-1 · 2.84 Impact Factor