Ekaterina Ya Ruta

International Sakharov Environmental University, Myenyesk, Minsk, Belarus

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Publications (1)2.3 Total impact

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    ABSTRACT: Binding of 1,8-anilinonaphthalene sulfonate (1,8-ANS) to main (HbA(1)) and glycosylated (HbA(1C)) forms of human oxyhemoglobin in the presence/absence of inositolhexaphosphate (IHP) in 50 mM potassium phosphate buffer, pH 7.4, was studied by time-correlated single photon counter with subnanosecond time resolution. The redistribution of contributions of the most long-lived and the most short-lived fluorescent decay components in the presence of IHP provides an evidence of the probe binding within oxyhemoglobin central cavity, namely DPG-binding site. Finally, it was shown that the fluorescent probe is extremely sensitive for hemoglobin central cavity modification, provided by the carbohydrate moiety in case of 1,8-ANS interactions with HbA(1C).
    Biochemical and Biophysical Research Communications 06/2004; 317(3):761-7. DOI:10.1016/j.bbrc.2004.03.111 · 2.30 Impact Factor

Publication Stats

9 Citations
2.30 Total Impact Points


  • 2004
    • International Sakharov Environmental University
      Myenyesk, Minsk, Belarus