E Szałek

Publications (2)0.66 Total impact

• Article: Pharmacokinetics and pharmacodynamics of ciprofloxacin in critically ill patients after the first intravenous administration of 400 mg.

  E Szałek, H Tomczak, A Kamińska, T Grabowski, P Smuszkiewicz, K Matysiak, A Wolc, Z Kaczmarek, E Grześkowiak
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  ABSTRACT: Purpose: To investigate the pharmacokinetics and pharmacodynamics of ciprofloxacin in critically ill patients after the first intravenous administration of 400 mg.Material/methods. Plasma concentrations were measured in 20 critically ill patients (mean [SD]; age, 55.5 [16.5] years; weight, 80.3 [16.9] kg; and creatinine clearance, 110.0 [71.5] mL/min). Four blood samples were drawn at the following time points 0, 0.5, 6, 8 hours after infusion. Ciprofloxacin concentrations were determined by high-performance liquid chromatography. Results. In the cases where ciprofloxacin was applied in targeted antibiotic therapy the minimum inhibitory concentrations (MIC) were ≤0.5 mg/l. The maximum and minimum plasma concentrations of ciprofloxacin were 1.74 (0.58-7.90) and 0.45 (0.16-2.96) mg/l, respectively. The main pharmacokinetic parameters for ciprofloxacin in the analyzed patients were as follows: kel, 0.21 h-1; t1/2kel, 3.37 h; AUC0-inf, 10.10 mgxh/l; AUMC0-last, 15.36 mgxh2/l; MRT, 1.71 h; Vd, 214.8 l; Cl, 39.70 l/h. Considering the maximum value of MIC (0.5 mg/l) only 30% and 25% of analyzed patients had desired values of the PK/PD indexes AUIC>125 and Cmax/MIC>10, respectively.Conclusions. The target plasma concentrations after the first dose of ciprofloxacin were reached only in a few critically ill patients. Considerable inter-subject variability for PK/PD parameters in ICU patients requires systematic monitoring.
  Advances in Medical Sciences 09/2012;
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  Available from: ptfarm.pl

  Article: Pharmaceutical availability of clobetasol-17-propionate from cream and ointment.

  S Dyderski, E Grześkowiak, E Szałek, A Mrzygłód
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  ABSTRACT: Kinetics of drug release from both compared preparations available as a cream and an ointment, was in vitro studied. A reversed-phase HPLC method was developed for the determination of clobetasol-17-propionate in lipophylic bases using clobetasol-17-butyrate as an internal standard. Analyses were performed using a C18 reversed-phase column with a mobile phase of methanol-water and ultraviolet detection at lambda=254 nm. The calibration curve was constructed for the concentration range 0.5-40.0 microg/ml. The method is simple, accurate and precise.
  Acta poloniae pharmaceutica 58(6):435-8. · 0.66 Impact Factor