Dong Seok Yang

University of Ulsan, Urusan, Ulsan, South Korea

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Publications (2)12.01 Total impact

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    ABSTRACT: The medial lemniscus (ML) plays a critical role in sensory function and skillful movement. Using combined functional MRI (fMRI) and diffusion tensor tractography (DTT), we attempted to identify the ML pathway and quantify the characteristics of the ML compared to the corticospinal tract (CST). Eleven young healthy subjects without any history of neurological disorder were recruited for this study. For tracking of the ML, a seed region of interest (ROI) was determined using the fMRI activation in the primary sensorimotor cortex (SM1) following proprioceptive input, and a target ROI was given in the ML area of the pons. We were able to locate the ML in 9 out of 11 subjects. All ML started from the ML area just posterior to the transpontine fiber in the pons, and ascended to the SM1 posterolaterally to the cerebral peduncle of the midbrain, the posterior limb of the internal capsule (PLIC), and the corona radiata along with the CST. The fractional anisotropy (FA) value of the ML was similar to that of the CST. We could identify the ML pathway in the human brain using the combined fMRI/DTT method. These results and technique will be helpful for research about the ML in the human brain.
    Neuroscience Letters 06/2009; 459(1):19-24. DOI:10.1016/j.neulet.2009.04.058 · 2.03 Impact Factor
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    ABSTRACT: We investigated whether the integrity of the corticospinal tract classified by diffusion tensor tractography (DTT) can predict the motor outcome in 25 patients with pontine infarct. DTTs were obtained in the early stage of stroke (5-30 days) and were classified into two groups (type A: the integrity of corticospinal tract was preserved around the infarct; type B: corticospinal tract was interrupted). DTT type A patients showed better motor function than the type B patients at 6 months after onset. DTT obtained at the early stage of pontine infarct appears to have predictive value for motor outcome in patients with pontine infarct.
    Annals of Neurology 10/2008; 64(4):460-5. DOI:10.1002/ana.21444 · 9.98 Impact Factor

Publication Stats

59 Citations
12.01 Total Impact Points


  • 2008–2009
    • University of Ulsan
      • • Department of Occupational and Environmental Medicine
      • • Department of Medicine
      Urusan, Ulsan, South Korea