David B Engel

Publications (1)2.55 Total impact

• Article: A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.

  Scott M Sheehan, John J Masters, Michael R Wiley, Stephen C Young, John W Liebeschuetz, Stuart D Jones, Christopher W Murray, Jeffrey B Franciskovich, David B Engel, Wayne W Weber, Jothirajah Marimuthu, Jeffrey A Kyle, Jeffrey K Smallwood, Mark W Farmen, Gerald F Smith
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  ABSTRACT: A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.
  Bioorganic & Medicinal Chemistry Letters 08/2003; 13(14):2255-9. · 2.55 Impact Factor