Daniela de la Rosa-Zamboni

Publications of Daniela de la Rosa-Zamboni

• Severe 2009 pandemic influenza A (H1N1) infection and increased mortality in patients with late and advanced HIV disease.

  Authors: Christopher E Ormsby, Daniela de la Rosa-Zamboni, Joel Vázquez-Pérez, Yuria Ablanedo-Terrazas, Ricardo Vega-Barrientos, María Gómez-Palacio, Akio Murakami-Ogasawara, Jorge A Ibarra-Ávalos, Dámaris Romero-Rodríguez, Santiago Avila-Ríos, Gustavo Reyes-Terán

  AIDS (London, England). 02/2011; 25(4):435-9.

  To describe the clinical course of infection by 2009 (H1N1) influenza virus in different stages of HIV disease. Prospective, observational study. During the pandemic period, HIV-infected patientsTo describe the clinical course of infection by 2009 (H1N1) influenza virus in different stages of HIV disease. Prospective, observational study. During the pandemic period, HIV-infected patients presenting respiratory symptoms at a third level referral hospital in Mexico City were tested for 2009 influenza A (H1N1) viral RNA. Clinical files were prospectively analyzed. Infection by H1N1 was confirmed in 30 (23.8%) of the total 126 HIV-infected patients studied. In the group of patients with 2009 H1N1 virus infection, 16 (53.3%) were hospitalized, 12 (40%) had active opportunistic infections and six (20%) died. In the group of 96 patients not infected with 2009 H1N1 virus, 54 (56.25%) were hospitalized with opportunistic infections and 12 (12.5%) died. For all hospitalized patients, being on HAART and having undetectable HIV viral loads at hospitalization was associated with higher survival (P = 0.019). Patients with 2009 H1N1 virus infection had a higher mortality rate, even after adjusting for HAART (P = 0.043). Coinfection by HIV and H1N1 2009 virus was more severe in patients with opportunistic infections, as shown by longer hospital stays (P = 0.0013), higher rates of hospitalization (P < 0.0001), use of mechanical ventilation (P = 0.0086) and death (P = 0.026). Delayed administration of oseltamivir in hospitalized patients was significantly associated with mortality (P = 0.0022). Our data suggest that infection by 2009 H1N1 is more severe in HIV-infected patients with late and advanced HIV disease than in well controlled patients under HAART.

• Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico.

  Authors: Rogelio Perez-Padilla, Daniela de la Rosa-Zamboni, Samuel Ponce de Leon, Mauricio Hernandez, Francisco Quiñones-Falconi, Edgar Bautista, Alejandra Ramirez-Venegas, Jorge Rojas-Serrano, Christopher E Ormsby, Ariel Corrales, Anjarath Higuera, Edgar Mondragon, Jose Angel Cordova-Villalobos

  The New England journal of medicine. 07/2009;

  BACKGROUND: In late March 2009, an outbreak of a respiratory illness later proved to be caused by novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in Mexico. We describe theBACKGROUND: In late March 2009, an outbreak of a respiratory illness later proved to be caused by novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in Mexico. We describe the clinical and epidemiologic characteristics of persons hospitalized for pneumonia at the national tertiary hospital for respiratory illnesses in Mexico City who had laboratory-confirmed S-OIV infection, also known as swine flu. METHODS: We used retrospective medical chart reviews to collect data on the hospitalized patients. S-OIV infection was confirmed in specimens with the use of a real-time reverse-transcriptase-polymerase-chain-reaction assay. RESULTS: From March 24 through April 24, 2009, a total of 18 cases of pneumonia and confirmed S-OIV infection were identified among 98 patients hospitalized for acute respiratory illness at the National Institute of Respiratory Diseases in Mexico City. More than half of the 18 case patients were between 13 and 47 years of age, and only 8 had preexisting medical conditions. For 16 of the 18 patients, this was the first hospitalization for their illness; the other 2 patients were referred from other hospitals. All patients had fever, cough, dyspnea or respiratory distress, increased serum lactate dehydrogenase levels, and bilateral patchy pneumonia. Other common findings were an increased creatine kinase level (in 62% of patients) and lymphopenia (in 61%). Twelve patients required mechanical ventilation, and seven died. Within 7 days after contact with the initial case patients, a mild or moderate influenza-like illness developed in 22 health care workers; they were treated with oseltamivir, and none were hospitalized. CONCLUSIONS: S-OIV infection can cause severe illness, the acute respiratory distress syndrome, and death in previously healthy persons who are young to middle-aged. None of the secondary infections among health care workers were severe. Copyright 2009 Massachusetts Medical Society.