Daniela Mueller

Publications (2)3.13 Total impact

• Article: Antimalarial activity of azafluorenone alkaloids from the Australian tree Mitrephora diversifolia.

  Daniela Mueller, Rohan A Davis, Sandra Duffy, Vicky M Avery, David Camp, Ronald J Quinn
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  ABSTRACT: Mass-directed isolation of the CH2Cl2/MeOH extract from the roots of the Australian tree Mitrephora diversifolia resulted in the purification of the new azafluorenone alkaloid 5,8-dihydroxy-6-methoxyonychine (1) together with the known natural product 5-hydroxy-6-methoxyonychine (2). The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 2 displayed IC(50) values of 9.9 and 11.4 microM, respectively, while 1 showed minimal activity.
  Journal of Natural Products 08/2009; 72(8):1538-40. · 3.13 Impact Factor
• Article: Antimalarial Activity of Azafluorenone Alkaloids from the Australian Tree Mitrephora diversifolia

  Daniela Mueller, Rohan Andrew Davis, Sandra Duffy, Vicky Marie Avery, David Brian Camp, Ronald J Quinn
  [show abstract] [hide abstract]
  ABSTRACT: Mass-directed isolation of the CH2Cl2/MeOH extract from the roots of the Australian tree Mitrephora diVersifolia resulted in the purification of the new azafluorenone alkaloid 5,8-dihydroxy-6-methoxyonychine (1) together with the known natural product 5-hydroxy-6-methoxyonychine (2). The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 2 displayed IC50 values of 9.9 and 11.4 μM, respectively, while 1 showed minimal activity. Yes Yes