Daniela Adorni

University Hospital of Parma, Parma, Emilia-Romagna, Italy

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Publications (9)9.08 Total impact

  • Blood transfusion = Trasfusione del sangue 01/2012; 10(4):1. DOI:10.2450/2012.0151-11 · 1.90 Impact Factor
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    Blood transfusion = Trasfusione del sangue 07/2011; 10(1):108-9. DOI:10.2450/2011.0019-11 · 1.90 Impact Factor
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    Daniela ADORNI, Stefano MAGAGNOLI
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    ABSTRACT: This paper (1) examines two areas of Italy, with very different political subcultures and production systems, with the aim of making a comparative analysis of the role of local government policies in stimulating growth processes over the thirty-year post war period. Historians now agree that the policies of Italian local governments were a major factor in the processes of economic growth and the spread of social services. They acted through a highly varied mix of policies, including regulatory processes (town planning, coordinated local programming, etc.), operations enabling institutions to provide the local environment with specific public goods (industrial estates, business services etc.) as well as redistribution policies (i.e. the setting up and spread of local welfare systems and local tax systems). This influential steering role of local administrations, marked in some cases by the gradual inception of specific institutional authoritativeness, was not distributed uniformly over the whole of Italy and there were significant asymmetries between areas. A comparative analysis is made of the "Emilia-Romagna model" of local government, controlled by an Italian Communist hegemony in a context of small and medium sized firms, and the model of the city of Turin, which was based on an industrial Ford model because of the presence of the Fiat factory. The two models are compared from the perspective of actors and their different interests. Our aim is to gauge the nature and intensity of the local institutional actions that accompanied and promoted the processes of development.
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    ABSTRACT: Platelet gel is being ever more frequently used to promote healing of cutaneous ulcers. However, the factors that determine the often variable clinical outcome of this procedure are still incompletely understood. The aims of this study were to demonstrate that platelet gel, even when obtained under strictly controlled conditions, produces highly variable outcomes in patients with cutaneous ulcers and to propose a method for in vitro standardisation of the biological properties of platelet gel. MATERIAL AND METHODS.: Patients were enrolled on the basis of a pre-defined protocol. Platelet concentrate was produced with standard methods, with a variability in platelet count among the different samples of less than 10%. The platelet gel for clinical use was obtained, under strictly standardized conditions, by adding thrombin and calcium gluconate to the concentrates. For in vitro studies, platelet gel, obtained from platelet-rich plasma from four donors, was frozen and thawed twice so as to increase gel contraction. The supernatant was used to modify cell proliferation, protein synthesis, and the expression of selected genes in cultures of human diploid fibroblasts. Seventeen patients (aged 44-78 years) with ulcers (4 diabetic, 11 vascular, 1 post-traumatic, 1 decubitus) were treated with platelet gel (4 autologous, 13 homologous). Complete re-epithelialisation of four ulcers (1 diabetic, 1 post-traumatic, 2 vascular) was obtained after applications of platelet gel (2 autologous, 2 homologous); in 11 other cases there was a greater than 50% reduction in the size of the ulcer. Two patients had no benefit. The supernatant of the platelet gel was able to promote dose-dependent proliferation and changes in gene expression as well as in metabolic activities related to protein synthesis. Although the use of platelet gel in the treatment of cutaneous ulcers is increasing, and conditions for its production are better standardised, very considerable variability of clinical outcomes is still observed, even within single centres, suggesting that there are differences in biological properties of platelet concentrates from individual patients which cannot be readily controlled with current techniques. The biological effects of the platelet gel supernatant described in this article may provide the basis for a simple biological validation of platelet preparations before their clinical use, so as to reduce this potentially important source of variability.
    Blood transfusion = Trasfusione del sangue 10/2010; 8(4):237-47. DOI:10.2450/2009.0118-09 · 1.90 Impact Factor
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    ABSTRACT: Cardiovascular disease, which is one of the main causes of mortality in industrialised countries, is ever increasingly the focus of prevention. In this study, called "Cardiorisk", we evaluated cardiovascular risk in the population of blood donors at the Service of Immunohaematology and Transfusion Medicine in Parma. Between January 2007 and December 2008, 6,172 consecutive blood donors (aged 35-65 years) were enrolled in this project which entailed calculating each subject's cardiovascular risk score, based on an evaluation of both unalterable risk factors (age and gender) and modifiable risk factors (total cholesterol, HDL, LDL, triglycerides, glycaemia, smoking, hypertension) as well as anti-hypertensive and/or cholesterol-lowering therapy. Of the 6,172 donors enrolled in the study, 5,039 (81.7%) had a low cardiovascular risk (score from 0-10), 774 (12.5%) had a moderate cardiovascular risk (score from 11-19) and 359 (5.8%) donors had a high cardiovascular risk (score from 20-28). In our opinion, the calculation of cardiovascular risk is an important instrument for preventive medicine in blood donors.
    Blood transfusion = Trasfusione del sangue 07/2010; 8(3):155-8. DOI:10.2450/2009.0097-09 · 1.90 Impact Factor
  • Stefano Magagnoli, Daniela Adorni
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    ABSTRACT: Chronic venous leg ulcers (CVLU) are chronic wounds, associated with long-standing venous hypertension, which have a poor prognosis for healing. In the process of wound healing the first step is represented by platelet aggregation and subsequent release of growth factors and other mediators, which play a key role in the repair response. Platelet gel (PG), a hemocomponent obtained by mixing platelets, thrombin, and calcium, is able, when applied topically, to release platelet mediators that likely favor CVLU healing. However, unstandardized protocols have been described in studies utilizing PG for the regeneration of a number of tissues, including CVLU; the relative clinical outcomes were hence highly variable. In our experience the topical use of PG, together with the strict adherence to the principles of good wound care, quickly promoted increased granulation tissue, followed by a complete CVLU epithelization. Although further studies and trials are needed to establish the major outcome affecting rules for optimal indications, preparation, and use of PG for CVLU treatment, PG can be undoubtedly considered a useful tool, able to improve the management of CVLU.
    Dermatologic Therapy 08/2008; 21 Suppl 1:S13-7. DOI:10.1111/j.1529-8019.2008.00196.x · 1.48 Impact Factor
  • Daniela Adorni
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    ABSTRACT: Since the unification of Italy, local institutions have played a key role in promoting processes of modernization at local level, frequently beyond the scope allowed by law. Local institutions were particularly active in the Fascist period, when the centre-periphery relationship was characterised by reciprocity and negotiation. The strength of a local administration depended to a great extent on the calibre of people it employed, from administrative staff right up to the Podestà.
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    D. Adorni, S. Magagnoli
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    ABSTRACT: Il paper rappresenta un primo passo verso una riflessione organica sul tema del decentramento istituzionale in relazione al problema dello sviluppo locale in un’ottica temporale di lungo periodo (partendo cioè dall’unificazione del Regno d’Italia) e intreccia tra loro più piani di analisi: dalle vicende che riguardano gli assetti istituzionali della nazione (sospesi costantemente all’interno del dibattito tra accentramento e decentramento) a quelle che riguardano invece la concreta attività degli enti politici periferici. L’analisi mostra come all’interno di un quadro istituzionale storicamente caratterizzato da un forte accentramento statale, emergano tuttavia i fili di una costante ricerca di protagonismo da parte delle istituzioni politiche locali, le quali, in modo particolare sebbene non esclusivo negli anni repubblicani, “forzano” i limiti normativi dei propri spazi di intervento, facendosi carico direttamente – seppure con intensità e modalità differenti nelle diverse aree territoriali del paese – dei problemi dello sviluppo economico locale.